5-CHLOROQUINOLIN-8-AMINE

Base Information

• Chemical Name: 5-CHLOROQUINOLIN-8-AMINE
• CAS No.: 5432-09-7
• Molecular Formula: C9H7 Cl N2
• Molecular Weight: 178.621
• Hs Code.: 2933499090
• Mol file: 5432-09-7.mol

Synonyms:Quinoline,8-amino-5-chloro- (4CI); 5-Chloro-8-quinolylamine; NSC 13700

Chemical Property of 5-CHLOROQUINOLIN-8-AMINE

Chemical Property:

• Vapor Pressure: 3.35E-05mmHg at 25°C
• Boiling Point: 354.4°Cat760mmHg
• Flash Point: 168.2°C
• PSA: 38.91000
• Density: 1.363g/cm³
• LogP: 3.05160

Purity/Quality:

99% ^*data from raw suppliers

8-Amino-5-chloroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-CHLOROQUINOLIN-8-AMINE

There total 6 articles about 5-CHLOROQUINOLIN-8-AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methanol (67-56-1) + 2-(chloromethyl)-N-(5-chloroquinolin-8-yl)-4-phenylbutanamide → 5-chloroquinolin-8-amine (5432-09-7) + methyl 2-(chloromethyl)-4-phenylbutanoate

Guidance literature:

With boron trifluoride diethyl etherate; at 100 ℃; for 24h; Reagent/catalyst; Sealed tube;

DOI:10.1039/c6cc00234j

Reference yield: 70.0%

8-amino quinoline (578-66-5) → 5-chloroquinolin-8-amine (5432-09-7) + 5,7-dichloro-8-aminoquinoline (36107-01-4)

Guidance literature:

With trichloroisocyanuric acid; In acetonitrile; at 20 ℃; regioselective reaction;

DOI:10.1039/c7sc04107a

Reference yield:

hydrogenchloride (7647-01-0,15364-23-5) + 8-nitroquinoline (607-35-2) → 8-amino quinoline (578-66-5) + 5-chloroquinolin-8-amine (5432-09-7)

Guidance literature:

upstream raw materials:

5-chloro-8-nitroquinoline

hydrogenchloride

8-nitroquinoline

methanol

Refernces

• 1、 Yang, Xinglin,Sun, Yonghui,Sun, Tian-Yu,Rao, Yu. "Auxiliary-assisted palladium-catalyzed halogenation of unactivated C(sp3)-H bonds at room temperature". supporting information. p. 6423 - 6426. Retrieved 2016/05/24.