4-oxo-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-2- carboxylic acid

Base Information

• Chemical Name: 4-oxo-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-2- carboxylic acid
• CAS No.: 459157-20-1
• Molecular Formula: C8H8N2O3
• Molecular Weight: 180.16
• Hs Code.: 2933399990
• Mol file: 459157-20-1.mol

Synonyms:4-Oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxylic acid;

Chemical Property of 4-oxo-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-2- carboxylic acid

Chemical Property:

Purity/Quality:

NLT 98% ^*data from raw suppliers

4-Oxo-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyridine-2-carboxylicacid ^*data from reagent suppliers

Safty Information:

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Technology Process of 4-oxo-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-2- carboxylic acid

There total 3 articles about 4-oxo-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-2- carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

diethyl 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2,5-dicarboxylate (459157-16-5) → 4-oxo-6,7-dihydro-5H-pyrazolo[1,5-a]pyridine-2-carboxylic acid (459157-20-1)

Guidance literature:

With hydrogenchloride; water; at 100 ℃; for 6h;

Reference yield:

diethyl 1H-pyrazole-3,5-dicarboxylate (37687-24-4) → 4-oxo-6,7-dihydro-5H-pyrazolo[1,5-a]pyridine-2-carboxylic acid (459157-20-1)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 3.5 h / 80 °C

2: potassium tert-butylate / tetrahydrofuran; toluene / 3.42 h / 20 - 90 °C

3: hydrogenchloride; water / 6 h / 100 °C

With hydrogenchloride; potassium tert-butylate; water; potassium carbonate; In tetrahydrofuran; toluene; acetonitrile;

Reference yield:

diethyl 1-(4-ethoxy-4-oxobutyl)-1H-pyrazole-3,5-dicarboxylate → 4-oxo-6,7-dihydro-5H-pyrazolo[1,5-a]pyridine-2-carboxylic acid (459157-20-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / tetrahydrofuran; toluene / 3.42 h / 20 - 90 °C

2: hydrogenchloride; water / 6 h / 100 °C

With hydrogenchloride; potassium tert-butylate; water; In tetrahydrofuran; toluene;

upstream raw materials:

diethyl 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2,5-dicarboxylate

diethyl 1H-pyrazole-3,5-dicarboxylate

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