37687-24-4

Basic information

• Product Name: DIETHYL 3,5-PYRAZOLEDICARBOXYLATE
• Synonyms: 3,5-PYRAZOLEDICARBOXYLIC ACID DIETHYL ESTER;1H-PYRAZOLE-3,5-DICARBOXYLIC ACID DIETHYL ESTER;LABOTEST-BB LT00441143;DIETHYL PYRAZOLE-3,5-DICARBOXYLATE;DIETHYL 3,5-PYRAZOLEDICARBOXYLATE;Diethyl pyrazole-3,5-dicarboxylate,99%;Diethyl1H-PYRAZOLE-3,5-DICARBOXYLATE;3,5-(Diethoxycarbonyl)-1H-pyrazole
• CAS NO: 37687-24-4
• Molecular Formula: C₉H₁₂N₂O₄
• Molecular Weight: 212.2
• Product Categories: Aromatic Esters;Building Blocks;Heterocyclic Building Blocks;Pyrazoles;Building Blocks;C9;Chemical Synthesis;Heterocyclic Building Blocks
• Mol File: 37687-24-4.mol
• Article Data: 18

Chemical Properties

• Melting Point: 55-58 °C(lit.)
• Boiling Point: 352.03°C (rough estimate)
• Flash Point: 173 °C
• Appearance: White to light yellow/Crystalline Powder
• Density: 1.249
• Vapor Pressure: 1.93E-05mmHg at 25°C
• Refractive Index: 1.5373 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 8.08±0.10(Predicted)
• CAS DataBase Reference: DIETHYL 3,5-PYRAZOLEDICARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIETHYL 3,5-PYRAZOLEDICARBOXYLATE(37687-24-4)
• EPA Substance Registry System: DIETHYL 3,5-PYRAZOLEDICARBOXYLATE(37687-24-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 37687-24-4(Hazardous Substances Data)

Usage

Chemical Properties

slightly yellow crystalline powder

InChI:InChI=1/C9H12N2O4/c1-3-14-8(12)6-5-7(11-10-6)9(13)15-4-2/h5H,3-4H2,1-2H3,(H,10,11)

Upstream product

• 3112-31-0 3,5-pyrazoledicarboxylic acid 
• 541-41-3 chloroformic acid ethyl ester 
• 140-88-5 ethyl acrylate 
• 104525-94-2 diethyl 4-diazo-2-pentenedioate 
• 623-73-4 diazoacetic acid ethyl ester 
• 876726-66-8 ethyl 3-hydroxy-2-diazo-3-(4-chlorophenyl)-propionate 
• 623-47-2 propynoic acid ethyl ester 
• 67-51-6 3,5-dimethyl-1H-pyrazole 
• 64-17-5 ethanol 
• 82706-83-0 diethyl Δ²-pyrazoline-3,5-dicarboxylate 

Downstream Products

• 75092-39-6 1-Methyl-1H-pyrazole-3,5-dicarboxylic acid 
• 115414-07-8 1-benzyl-3,5-bis(hydroxymethyl)pyrazole 
• 115414-10-3 1-benzyl-3,5-bis(bromomethyl)pyrazole 
• 90421-57-1 1-methylpyrazole-3,5-dicarbonyl chloride 
• 623906-52-5 diethyl 1-(2-fluorobenzyl)-1H-pyrazole-3,5-dicarboxylate 
• 847573-68-6 1H-pyrazole-3,5-dicarbonitrile 
• 1397683-79-2 1H-pyrazole-3,5-dicarboxamide 
• 951626-95-2 ethyl 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate 
• 1338563-40-8 ethyl 5-benzyl-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate 
• 1349901-71-8 C₃₆H₄₃N₉O₄ 
• 1349901-70-7 C₃₆H₄₁N₉O₄ 
• 1349901-69-4 pyrrolidin amide 
• 1349901-68-3 C₃₂H₃₄N₈O₄ 
• 1349901-67-2 C₃₁H₃₂N₈O₄ 

Relevant articles and documents

In search of acyclic analogues as universal nucleosides in degenerate probes

Five acyclic nucleoside analogues with unnatural base moieties have been synthesized of which three successfully were incorporated into oligonucleotides. The acyclic analogue containing the base 5-nitroindazole was the least discriminating and should be further pursued for use as a universal nucleoside analogue.

FUSED RING PYRIMIDONE DERIVATIVES FOR USE IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES

Provided are compounds according to any of Formula (I-1) to (I-7), pharmaceutical compositions comprising at least one of said compounds, their use as a medicament, and their use in treating chronic hepatitis B virus (HBV) infection. Methods for preparing compounds according to any of Formula (I-1) to (I-7) are also provided.

Synthetic method for one-step C-N construction C-S of C-C(I), (C) and (C)-(C) bonds (by machine translation)

An acid load type catalyst is used under the heating C - C condition C - N, C - S and under the heating condition, the α - protonation of the heavy nitrogen ester is carried out, and the construction of the keys is realized in one step, and the method α -

[3 + 2] cycloaddition and subsequent oxidative dehydrogenation between alkenes and diazo compounds: A simple and direct approach to pyrazoles using TBAI/TBHP

A novel Bu4NI-catalyzed pyrazole formation reaction is well described via sequential [3 + 2] cycloaddition and oxidative dehydrogenation reactions using TBHP as the primary oxidant. In comparison with previous cases toward pyrazoles from alkene