6-TRIFLUOROMETHYL-1H-PYRROLO[2,3-B]PYRIDINE

Base Information

• Chemical Name: 6-TRIFLUOROMETHYL-1H-PYRROLO[2,3-B]PYRIDINE
• CAS No.: 1060802-93-8
• Molecular Formula: C8H5F3N2
• Molecular Weight: 186.136
• Mol file: 1060802-93-8.mol

Synonyms:6-TRIFLUOROMETHYL-1H-PYRROLO[2,3-B]PYRIDINE;1H-pyrrolo[2,3-b]pyridine, 6-(trifluoroMethyl)-;6-TrifluoroMethyl-7-azaindole-2-carbaldehyde;6-(TrifluoroMethyl)-7-azaindole

Chemical Property of 6-TRIFLUOROMETHYL-1H-PYRROLO[2,3-B]PYRIDINE

Chemical Property:

• PSA: 28.68000
• LogP: 2.58170

Purity/Quality:

99%, ^*data from raw suppliers

6-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-TRIFLUOROMETHYL-1H-PYRROLO[2,3-B]PYRIDINE

There total 7 articles about 6-TRIFLUOROMETHYL-1H-PYRROLO[2,3-B]PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

→ ?6-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine (1060802-93-8)

Guidance literature:

With water; sodium hydroxide; In methanol; at 20 ℃; for 4h;

Reference yield:

methyl 6-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate (1420070-68-3) → ?6-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine (1060802-93-8)

Guidance literature:

With methanol; sodium hydroxide; at 20 ℃; for 16h;

Reference yield:

C11H9F3N2O2 → ?6-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine (1060802-93-8)

Guidance literature:

With methanol; sodium hydroxide; at 20 ℃; for 2h;

DOI:10.1016/j.bmcl.2014.08.029

upstream raw materials:

ethyl 6-chloro-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

7-Azaindole

1H-Pyrrolo[2,3-b]pyridine-7-oxide

6-Iodo-1-methoxycarbonyl-1H-pyrrolo<2,3-b>pyridine

Downstream raw materials:

N-(2-(3-bromo-6-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl)-N-ethylcyclopropanecarboxamide

tert-butyl 2-(1-(2-((N-ethylcyclopropanecarboxamido)methyl)-4-(trifluoromethyl)phenyl)-6-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)acetate

C₂₄H₂₁F₆N₃O₃

N-ethyl-N-(5-(trifluoromethyl)-2-(6-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)benzyl)cyclopropanecarboxamide

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