2-Cyclohex-3-enylethylaMine

Base Information

• Chemical Name: 2-Cyclohex-3-enylethylaMine
• CAS No.: 40496-65-9
• Molecular Formula: C8H15N
• Molecular Weight: 125.21
• Mol file: 40496-65-9.mol

Synonyms:2-Cyclohex-3-enyl-ethylamine;2-(3-Cyclohexenyl)ethylamine;

Chemical Property of 2-Cyclohex-3-enylethylaMine

Chemical Property:

• Melting Point: 185 - 187 °C
• PSA: 26.02000
• LogP: 2.39180

Purity/Quality:

2-(Cyclohex-3-en-1-yl)ethan-1-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Cyclohex-3-enylethylaMine

There total 6 articles about 2-Cyclohex-3-enylethylaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

(E)-1-(3-cyclohexen-1-yl)-2-nitroethene (133777-63-6) → 1-amino-2-(3-cyclohexen-1-yl) ethane (40496-65-9)

Guidance literature:

With sulfuric acid; In water; isopropyl alcohol; at 10 - 15 ℃; electrolysis;

Reference yield:

potassium cyanide + [(cyclohex-3-en-1-yl)methyl]methanesulfonate (108541-48-6) → 1-amino-2-(3-cyclohexen-1-yl) ethane (40496-65-9)

Guidance literature:

potassium cyanide; [(cyclohex-3-en-1-yl)methyl]methanesulfonate; With 18-crown-6 ether; In tetrahydrofuran; at 85 ℃; for 24h; Inert atmosphere;

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 85 ℃; for 24h; Inert atmosphere;

DOI:10.1515/znb-2016-0129

Reference yield:

3-Cyclohexene-1-carboxaldehyde (100-50-5,61746-36-9) → 1-amino-2-(3-cyclohexen-1-yl) ethane (40496-65-9)

Guidance literature:

Multi-step reaction with 4 steps

1: KF / propan-2-ol / 20 h / Ambient temperature

2: DMAP / diethyl ether / 20 h / Ambient temperature

3: NaOAc / ethyl acetate / 12 h / Ambient temperature

4: 69 percent / 0.3 M H₂SO₄ / propan-2-ol; H₂O / 10 - 15 °C / electrolysis

With dmap; potassium fluoride; sulfuric acid; sodium acetate; In diethyl ether; water; ethyl acetate; isopropyl alcohol;

upstream raw materials:

(E)-1-(3-cyclohexen-1-yl)-2-nitroethene

2-Nitro-1-hydroxy-1--aethan

1-(3-Cyclohexen-1-yl)-2-nitroethylacetat

3-Cyclohexene-1-carboxaldehyde

Refernces

• 1、 Wessling, Michael,Schaefer, Hans J.. "Cathodic Reduction of 1-Nitroalkenes to Oximes and Primary Amines". . p. 2303 - 2306. Retrieved 2007/10/02.