METHADONE

Base Information

• Chemical Name: METHADONE
• CAS No.: 297-88-1
• Molecular Formula: C21H27NO
• Molecular Weight: 309.45
• Mol file: 297-88-1.mol

Synonyms:methadone base;6-(Dimethylamino)-4,4-diphenyl-3-heptanone DL-mixture

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Chemical Property of METHADONE

Chemical Property:

• Melting Point: 80°C
• Refractive Index: 1.5614 (estimate)
• Boiling Point: 449.71°C (rough estimate)
• PSA: 20.31000
• Density: 1.0350 (rough estimate)
• LogP: 4.29200

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHADONE

There total 20 articles about METHADONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(R)-methadone hydrochloride (5967-73-7) → Methadone (76-99-3,297-88-1)

Guidance literature:

With ammonium hydroxide; In water; at 25 - 30 ℃; pH=8.5 - 9.5;

Reference yield: 99.0%

(6R)-6-(dimethylamino)-4,4-diphenyl-3-heptanone-(+)-N-tosyl glutamate salt → levomethadone (125-58-6,297-88-1)

Guidance literature:

With ammonium hydroxide; In water; at 25 - 30 ℃; for 1h; pH=8.5 - 9.5;

Reference yield:

d-methadone N-(4-nitro-benzoyl)-L-glutamate salt → (S)-methadone (5653-80-5,297-88-1)

Guidance literature:

With sodium hydroxide; In water; ethyl acetate; at 15 - 40 ℃;

upstream raw materials:

ethylmagnesium iodide

(R,S)-2,2-diphenyl-4-dimethylaminopentanenitrile

ethylmagnesium bromide

1,1-diphenylbutan-2-one

Downstream raw materials:

recipavrin

(+)-Methadone hydrochloride

(R,S)-2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine