5967-73-7

Basic information

• Product Name: (R)-dimethyl(1-methyl-4-oxo-3,3-diphenylhexyl)ammonium chloride
• Synonyms: (R)-dimethyl(1-methyl-4-oxo-3,3-diphenylhexyl)ammonium chloride;Levomethadone hydrochloride;Laevomethanone;l-Methadone hydrochloride;(R)-Methadone Hydrochloride;FJQXCDYVZAHXNS-UNTBIKODSA-N
• CAS NO: 5967-73-7
• Molecular Formula: C₂₁H₂₇NO*ClH
• Molecular Weight: 345.90612
• EINECS: 227-756-6
• Product Categories: Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals
• Mol File: 5967-73-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 220-227°C
• Boiling Point: 423.7°C at 760 mmHg
• Flash Point: 126.5°C
• Appearance: /
• Vapor Pressure: 2.2E-07mmHg at 25°C
• Storage Temp.: Controlled Substance, -20?C Freezer
• Solubility: Soluble in water, freely soluble in ethanol (96 per cent).
• CAS DataBase Reference: (R)-dimethyl(1-methyl-4-oxo-3,3-diphenylhexyl)ammonium chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-dimethyl(1-methyl-4-oxo-3,3-diphenylhexyl)ammonium chloride(5967-73-7)
• EPA Substance Registry System: (R)-dimethyl(1-methyl-4-oxo-3,3-diphenylhexyl)ammonium chloride(5967-73-7)

Safety Data

• Hazardous Substances Data: 5967-73-7(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

(R)-dimethyl(1-methyl-4-oxo-3,3-diphenylhexyl)ammonium chloride can be used as a component of pharmaceuticals used in the treatment of opioid dependence.

Safety Profile

Poison by intravenous, subcutaneous, and intraperitoneal routes. Human systemic effects by ingestion: hallucinations, distorted perceptions, and analgesia. Caution: Abuse leads to habituation or addiction. When heated to decomposition it emits very toxic fumes of Cland NOx. See also METHADONE HYDROCHLORIDE.

InChI:InChI=1/C21H27NO.ClH/c1-5-20(23)21(16-17(2)22(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19;/h6-15,17H,5,16H2,1-4H3;1H/t17-;/m1./s1

Upstream product

• 157431-09-9 Ν,Ν-dimethyl D-alanine 
• 133814-25-2 (R)-2-(dimethylamino)propane-1-ol 
• 925-90-6 ethylmagnesium bromide 
• 78208-11-4 levomethadone nitrile hydrochloride 
• 125-58-6 levomethadone 
• 1095-90-5 methadone hydrochloride 
• 86-29-3 Diphenylacetonitrile 
• 7576-16-1 (R)-(-)-2,2-diphenyl-4-dimethylaminopentanenitrile 

Downstream Products

• 76-99-3 Methadone 

Relevant articles and documents

SYNTHESIS OF LEVOMETHADONE HYDROCHLORIDE

A method for synthesizing levomethadone hydrochloride including producing (R)-2-(dimethylamino)propan-1-ol by reducing N,N-dimethyl-D-alanine using borax, forming (R)-1-chloro-N,N-dimethylpropane-2-amine hydrochloride by chlorinating the (R)-2-(dimethylamino)propan-1-ol, synthesizing levomethadone nitrile hydrochloride by mixing the (R)-1-chloro-N,N-dimethylpropane-2-amine and diphenylacetonitrile with potassium t-butoxide and producing levomethadone hydrochloride by exposing the levomethadone nitrile hydrochloride to a Grignard reagent.

"A NOVEL PROCESS FOR CHIRAL RESOLUTION OF HIGHLY PURE (6R)-6-(DIMETHYLAMINO)-4,4-DIPHENYL-3-HEPTANONE FROM RACEMIC METHADONE HYDROCHLORIDE"

The present invention discloses an improved process for preparing pure (dimethylarnino)-4,4-diphenyl-3-heptanone and its hydrochloride salt.

Synthesis of optically active methadones, LAAM and bufuralol by lipase-catalysed acylations

(R)- and (S)-Methadones and levo-α-acetylmethadol (LAAM) have been synthesised starting from lipase-catalysed acylation of dimethylaminopropan-2-ol. An approach to the synthesis of (R)-bufuralol is also presented.