N-Methyl-1-(phenylMethyl)-1H-indole-5-ethanesulfonaMide

Base Information

Chemical Name:N-Methyl-1-(phenylMethyl)-1H-indole-5-ethanesulfonaMide
CAS No.:894351-85-0
Molecular Formula:C18H20N2O2S
Molecular Weight:328.435
Hs Code.:
Mol file:894351-85-0.mol

Synonyms:N-Methyl-[2-(1-benzylindol-5-yl)ethane-1-sulfonaMide;N-Methyl-1-(phenylMethyl)-1H-indole-5-ethanesulfonaMide;1H-Indole-5-ethanesulfonamide, N-methyl-1-(phenylmethyl)-

Suppliers and Price of N-Methyl-1-(phenylMethyl)-1H-indole-5-ethanesulfonaMide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-Methyl-[2-(1-benzylindol-5-yl)ethane-1-sulfonamide
10mg
$ 120.00

Medical Isotopes, Inc.
N-Methyl-[2-(1-benzylindol-5-yl)ethane-1-sulfonamide
10 mg
$ 620.00

Total 2 raw suppliers

Chemical Property of N-Methyl-1-(phenylMethyl)-1H-indole-5-ethanesulfonaMide

Chemical Property:

PSA：59.48000
LogP:4.25300
Storage Temp.:-20°C Freezer
Solubility.:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:: N-Methyl-[2-(1-benzylindol-5-yl)ethane-1-sulfonamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Intermediate for the preparation of Naratriptan and other

Technology Process of N-Methyl-1-(phenylMethyl)-1H-indole-5-ethanesulfonaMide

There total 8 articles about N-Methyl-1-(phenylMethyl)-1H-indole-5-ethanesulfonaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 894351-84-9
2-(1-benzyl-1H-indol-5-yl)ethenesulfonic acid methylamide

: 894351-85-0
2-(1-benzyl-1H-indol-5-yl)ethanesulfonic acid methylamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 2h; under 3750.3 Torr;
DOI:10.3987/COM-06-10670

Reference yield:

: 1268266-01-8
2-(4-benzylamino-3-ethynylphenyl)ethanesulfonic acid methylamide

: 894351-85-0
2-(1-benzyl-1H-indol-5-yl)ethanesulfonic acid methylamide

Guidance literature:: With potassium tert-butylate; In 1-methyl-pyrrolidin-2-one; at 80 - 85 ℃;

Reference yield:

: 63263-84-3
N-benzylindoline-5-carboxaldehyde

: 894351-85-0
2-(1-benzyl-1H-indol-5-yl)ethanesulfonic acid methylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 75 percent / DDQ / CH₂Cl₂ / 3 h / 0 °C

2.1: t-BuOK / tetrahydrofuran / 1 h / -78 °C

2.2: 73 percent / tetrahydrofuran / -78 - 0 °C

3.1: 84 percent / H₂ / 10 percent Pd/C / methanol / 2 h / 20 °C / 3750.3 Torr

With potassium tert-butylate; hydrogen; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.3987/COM-06-10670