N-methyl-3-chloro-3-phenylpropylamine Hydrochloride

Base Information

• Chemical Name: N-methyl-3-chloro-3-phenylpropylamine Hydrochloride
• CAS No.: 128036-32-8
• Molecular Formula: C10H14ClN.ClH
• Molecular Weight: 220.142
• DSSTox Substance ID: DTXSID90591811
• Mol file: 128036-32-8.mol

Synonyms:128036-32-8;N-methyl-3-chloro-3-phenylpropylamine Hydrochloride;3-chloro-N-methyl-3-phenylpropan-1-amine;hydrochloride;N-Methyl-3-chloro-3-phenyl propylamine HCl;3-chloro-N-methyl-3-phenylpropan-1-amine hydrochloride;SCHEMBL2074868;DTXSID90591811;EN300-8157141;(3-chloro-3-phenylpropyl)(methyl)amine hydrochloride;3-Chloro-N-methyl-3-phenylpropan-1-amine--hydrogen chloride (1/1)

Chemical Property of N-methyl-3-chloro-3-phenylpropylamine Hydrochloride

Chemical Property:

• PSA: 12.03000
• LogP: 3.76890
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 219.0581549
• Heavy Atom Count: 13
• Complexity: 110

Purity/Quality:

98%min ^*data from raw suppliers

N-METHYL-3-CHLORO-3-PHENYLPROPYLAMINE HYDROCHLORIDE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNCCC(C1=CC=CC=C1)Cl.Cl

Technology Process of N-methyl-3-chloro-3-phenylpropylamine Hydrochloride

There total 1 articles about N-methyl-3-chloro-3-phenylpropylamine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-methylamino-1-phenylpropan-1-ol (42142-52-9) → 3-chloro-N-methyl-3-phenylpropan-1-amine hydrochloride (128036-32-8)

Guidance literature:

With thionyl chloride; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield: 97.0%

3-chloro-N-methyl-3-phenylpropan-1-amine hydrochloride (128036-32-8) + acetyl chloride (75-36-5) → C12H16ClNO (1020301-87-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 1.5h;

Reference yield: 94.0%

3-chloro-N-methyl-3-phenylpropan-1-amine hydrochloride (128036-32-8) + benzyl chloroformate (501-53-1,94274-21-2) → C18H20ClNO2 (1020301-79-4)

Guidance literature:

3-chloro-N-methyl-3-phenylpropan-1-amine hydrochloride; With sodium hydroxide; In water; ethyl acetate; at 5 - 10 ℃; for 1h;

benzyl chloroformate; In water; ethyl acetate; at 5 - 10 ℃; for 2 - 3h;

upstream raw materials:

3-methylamino-1-phenylpropan-1-ol

Downstream raw materials:

C₁₂H₁₆ClNO

tert-butyl (3-chloro-3-phenylpropyl)(methyl)carbamate

C₁₈H₂₀ClNO₂