methyl 2-iodo-4-(trifluoromethyl)benzoate

Base Information

• Chemical Name: methyl 2-iodo-4-(trifluoromethyl)benzoate
• CAS No.: 1236303-09-5
• Molecular Formula: C9H6F3IO2
• Molecular Weight: 330.045
• Hs Code.: 2916399090
• Mol file: 1236303-09-5.mol

Synonyms:methyl 4-trifluoromethyl-2-iodobenzoate;METHYL 2-IODO-4-TRIFLUROMETHYLBENZOATE;2-iodo-4-trifluoromethyl-benzoic acid methyl ester;

Chemical Property of methyl 2-iodo-4-(trifluoromethyl)benzoate

Chemical Property:

• PSA: 26.30000
• LogP: 3.09660
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%+ ^*data from raw suppliers

Methyl2-Iodo-4-(trifluoromethyl)benzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 2-iodo-4-(trifluoromethyl)benzoate

There total 5 articles about methyl 2-iodo-4-(trifluoromethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-Amino-4-(trifluoromethyl)benzoate (61500-87-6) → methyl 2-iodo-4-(trifluoromethyl)benzoate (1236303-09-5)

Guidance literature:

methyl 2-Amino-4-(trifluoromethyl)benzoate; With toluene-4-sulfonic acid; In acetonitrile; Inert atmosphere;

With 4-bromo-1-(2,2-difluorovinyl)-2-iodobenzene; sodium nitrite; In water; acetonitrile; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.8b02128

Reference yield:

2-iodo-4-(trifluoromethyl)benzoic acid (54507-44-7) → methyl 2-iodo-4-(trifluoromethyl)benzoate (1236303-09-5)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / Inert atmosphere

2: oxalyl dichloride / dichloromethane / 0.5 h / Inert atmosphere

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1039/c3ra42474j

Reference yield:

2-amino-4-trifluoromethylbenzoic acid (402-13-1) → methyl 2-iodo-4-(trifluoromethyl)benzoate (1236303-09-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 - 5 °C / Inert atmosphere

1.2: 1 h / 10 - 90 °C / Inert atmosphere

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / Inert atmosphere

3.1: oxalyl dichloride / dichloromethane / 0.5 h / Inert atmosphere

With hydrogenchloride; oxalyl dichloride; N,N-dimethyl-formamide; sodium nitrite; In dichloromethane; water;

DOI:10.1039/c3ra42474j

upstream raw materials:

2-iodo-4-(trifluoromethyl)benzoic acid

methanol

C₈H₃ClF₃IO

2-amino-4-trifluoromethylbenzoic acid

Downstream raw materials:

2-cyclohexyl-4-trifluoromethyl-benzoic acid methyl ester

methyl 2-[(diethoxyphosphoryl)difluoromethyl]-4-(trifluoromethyl)benzoate

(2-iodo-4-(trifluoromethyl)phenyl)methanol

methyl 4-trifluoromethyl-2-((E)-4-hydroxybut-1-enyl)benzoate

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