methyl 6-bromobenzo[d][1,3]dioxole-4-carboxylate

Base Information

• Chemical Name: methyl 6-bromobenzo[d][1,3]dioxole-4-carboxylate
• CAS No.: 33842-18-1
• Molecular Formula: C9H7BrO4
• Molecular Weight: 259.05
• Hs Code.: 2932999099
• Mol file: 33842-18-1.mol

Synonyms:Methyl 6-bromo-1,3-benzodioxole-4-carboxylate;Methyl 6-broMobenzo[d][1,3]dioxole-4-carboxylate;1,3-Benzodioxole-4-carboxylic acid, 6-bromo-, methyl ester

Chemical Property of methyl 6-bromobenzo[d][1,3]dioxole-4-carboxylate

Chemical Property:

• PSA: 44.76000
• LogP: 1.96440
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl6-bromobenzo[d][1,3]dioxole-4-carboxylate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 6-bromobenzo[d][1,3]dioxole-4-carboxylate

There total 6 articles about methyl 6-bromobenzo[d][1,3]dioxole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methyl 5-bromo-2,3-dihydroxybenzoate (105603-49-4) + 1,1-dibromomethane (74-95-3) → methyl 6-bromobenzo[d][1,3]dioxole-4-carboxylate (33842-18-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃;

Reference yield: 84.0%

benzo[1,3]dioxole-4-carboxylic acid methyl ester (33842-16-9) → methyl 6-bromobenzo[d][1,3]dioxole-4-carboxylate (33842-18-1)

Guidance literature:

With bromine; sodium acetate; acetic acid; at 20 ℃; for 12h;

DOI:10.1039/c9ob00892f

Reference yield:

methyl-2,3-dihydroxybenzoate (2411-83-8) → methyl 6-bromobenzo[d][1,3]dioxole-4-carboxylate (33842-18-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium fluoride / N,N-dimethyl-formamide / 0.5 h

1.2: 30 h / 110 °C

2.1: acetic acid; sodium acetate; bromine / 12 h / 20 °C

With potassium fluoride; bromine; sodium acetate; acetic acid; In N,N-dimethyl-formamide;

DOI:10.1039/c9ob00892f

upstream raw materials:

2,3-dihydroxy-5-bromobenzoic acid

2,3-Dihydroxybenzoic acid

methyl 5-bromo-2,3-dihydroxybenzoate

1,1-dibromomethane