5-BROMO-2,3-DIFLUORO-BENZALDEHYDE

Base Information

• Chemical Name: 5-BROMO-2,3-DIFLUORO-BENZALDEHYDE
• CAS No.: 633327-22-7
• Molecular Formula: C7H3BrF2O
• Molecular Weight: 221.001
• Hs Code.: 2913000090
• Mol file: 633327-22-7.mol

Synonyms:5-Bromo-2,3-difluoro benzaldehyde;

Chemical Property of 5-BROMO-2,3-DIFLUORO-BENZALDEHYDE

Chemical Property:

• Boiling Point: 230.0±35.0 °C(Predicted)
• PSA: 17.07000
• Density: 1.758±0.06 g/cm3(Predicted)
• LogP: 2.53980
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-2,3-difluorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-2,3-DIFLUORO-BENZALDEHYDE

There total 3 articles about 5-BROMO-2,3-DIFLUORO-BENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,3-difluorobenzaldehyde (2646-91-5) → 5-bromo-2,3-difluorobenzaldehyde (633327-22-7)

Guidance literature:

With N-Bromosuccinimide; sulfuric acid; at 60 ℃; for 12h;

Reference yield: 85.0%

1-bromo-3,4-difluorobenzene (348-61-8) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 5-bromo-2,3-difluorobenzaldehyde (633327-22-7)

Guidance literature:

With n-butyllithium; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; at -5 - 5 ℃; for 4.5h;

Reference yield:

5-bromo-2,3-difluoro-4-trimethylsilanylbenzaldehyde (633327-21-6) → 5-bromo-2,3-difluorobenzaldehyde (633327-22-7)

Guidance literature:

With water; cesium fluoride; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 1h;

upstream raw materials:

5-bromo-2,3-difluoro-4-trimethylsilanylbenzaldehyde

2,3-difluorobenzaldehyde

1-bromo-3,4-difluorobenzene

N,N-dimethyl-formamide

Downstream raw materials:

(5-bromo-2,3-difluorophenyl)methanol

5-bromo-2,3-difluorobenzonitrile

(E)-5-bromo-2,3-difluorobenzaldehyde O-methyl oxime

2-[3-(difluoromethyl)-4-fluoro-phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane