6-Aminoisoquinolin-1-ol

Base Information

• Chemical Name: 6-Aminoisoquinolin-1-ol
• CAS No.: 216099-46-6
• Molecular Formula: C9H8N2O
• Molecular Weight: 160
• Hs Code.: 2933499090
• Mol file: 216099-46-6.mol

Synonyms:6-Aminoisoquinolin-1-ol;6-Aminoisoquinolin-1(2H)-one;1-Oxoisoquinolin-6-amine, 6-Aminoisoquinolin-1-ol;6-AMino-1(2H)-Isoquinolinone

Chemical Property of 6-Aminoisoquinolin-1-ol

Chemical Property:

• PSA: 58.88000
• LogP: 1.69150
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

6-Aminoisoquinolin-1(2H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Aminoisoquinolin-1(2H)-one can be used to treat ocular disease.

Technology Process of 6-Aminoisoquinolin-1-ol

There total 2 articles about 6-Aminoisoquinolin-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

6-bromo-2H-isoquinoline-1-one (82827-09-6) → 6-aminoisoquinolin-1(2H)-one (216099-46-6)

Guidance literature:

6-bromo-2H-isoquinoline-1-one; With Benzophenone imine; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In toluene; at 105 ℃; for 72h;

With methanol; hydroxylamine hydrochloride; sodium acetate; In toluene; at 20 ℃; for 72h;

Reference yield: 78.0%

6-acetamido isoquinolin-1-one (143074-78-6) → 6-aminoisoquinolin-1(2H)-one (216099-46-6)

Guidance literature:

6-acetamido isoquinolin-1-one; With hydrogenchloride; In water; at 65 ℃; for 2h;

With ammonia; In water; at 60 ℃;

Reference yield:

6-aminoisoquinolin-1(2H)-one (216099-46-6) + benzyl isothiocyanate (3173-56-6) → 1-benzyl-3-(1-oxo-1,2-dihydro-isoquinolin-6-yl)-urea (1013117-39-9)

Guidance literature:

In ISOPROPYLAMIDE; at 60 ℃;

upstream raw materials:

6-acetamido isoquinolin-1-one

6-bromo-2H-isoquinoline-1-one

Downstream raw materials:

1-benzyl-3-(1-oxo-1,2-dihydro-isoquinolin-6-yl)-urea

C₁₇H₁₄N₂O₃