82827-09-6

Basic information

• Product Name: 6-BROMO-2H-ISOQUINOLIN-1-ONE
• Synonyms: 6-BROMO-2H-ISOQUINOLIN-1-ONE;6-BROMOISOQUINOLIN-1-ONE;6-bromoisoquinolin-1(2H)-one;6-broMo-1,2-dihydroisoquinolin-1-one;6-broMo-1,2-dihydro-1-oxoisoquinoline;6-BroMo-2H-isoquinolin-1-one, 95+%;6-bromo-2H-isoquinoline-1-one
• CAS NO: 82827-09-6
• Molecular Formula: C₉H₆BrNO
• Molecular Weight: 224.05
• Mol File: 82827-09-6.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 442.634 °C at 760 mmHg
• Flash Point: 221.498 °C
• Appearance: /
• Density: 1.62 g/cm³
• Storage Temp.: 2-8°C
• PKA: 12.20±0.20(Predicted)
• CAS DataBase Reference: 6-BROMO-2H-ISOQUINOLIN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-2H-ISOQUINOLIN-1-ONE(82827-09-6)
• EPA Substance Registry System: 6-BROMO-2H-ISOQUINOLIN-1-ONE(82827-09-6)

Safety Data

• Hazardous Substances Data: 82827-09-6(Hazardous Substances Data)

Usage

Uses

6-Bromo-2H-isoquinolin-1-one was used as a reagent in the fragment-based discovery of ROCK-I inhibitors derived from 6-substituted isoquinolin-1-amine and also used in the discovery of novel isoquinolone PDK1 inhibitors which offer a potentially new therapeutic modality for cancer treatment.

Upstream product

• 223671-16-7 6-bromoisoquinoline nitrogen oxide 
• 13162-05-5 n-vinylformamide 
• 586-76-5 4-Bromobenzoic acid 
• 586-75-4 4-chlorobenzoyl chloride 
• 108-05-4 vinyl acetate 
• 1352801-45-6 (4-bromophenyl)formamido 2,2-dimethylpropanoate 
• 1034558-65-0 (E)-1-bromo-3-(2-isocyanatovinyl)benzene 
• 1220229-19-5 (E)-4-bromo-2-(2-(dimethylamino)vinyl)benzonitrile 
• 205055-63-6 6-bromo-1-chloroisoquinoline 
• 14473-91-7 3-Bromocinnamic acid 
• 34784-05-9 6-bromo-isoquinoline 

Downstream Products

• 1036712-60-3 1-benzyloxy-6-bromo-isoquinoline 
• 1036712-58-9 6-bromo-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one 
• 864866-92-2 6-bromo-2-methylisoquinoline-1(2H)-one 
• 1184920-35-1 methyl 1-oxo-1,2-dihydroisoquinoline-6-carboxylate 
• 1301214-60-7 1,2-dihydro-1-oxoisoquinoline-6-carboxylic acid 
• 444898-85-5 C₃₅H₂₆BrNO₈ 
• 205055-63-6 6-bromo-1-chloroisoquinoline 
• 1070292-54-4 4-methyl-3-(1-oxo-1,2-dihydroisoquinolin-6-yl)benzoic acid methyl ester 

Relevant articles and documents

Light-induced [2 + 2] cycloadditions for the construction of cyclobutane-fused pyridinyl sulfonyl fluorides

Cyclobutanes are an important class of motifs present in a wide range of natural products and other biologically significant molecules. A photocatalytic [2 + 2] cycloaddition between pyridones or isoquinolones and ethenesulfonyl fluoride was achieved, providing a portal to a class of unique cyclobutane-fused pyridinyl sulfonyl fluorides with quaternary rigid rings (30 examples). Further applications of these novel sulfonyl fluoride molecules in SuFEx click chemistry were also accomplished, providing the corresponding sulfonates and sulphonamides with reasonable yields.

Divergent Synthesis of Isoquinolone and Isocoumarin Derivatives by the Annulation of Benzoic Acid with N-Vinyl Amide

A simple and efficient method for the synthesis of isoquinolone and isocoumarin derivatives is reported. The method for the first time provides a one-step divergent synthesis of important isoquinolone and isocoumarin skeletons from benzoic acid by switching the coupling partners. In addition, a reliable mechanism has been proposed on the basis of experimental investigations, including kinetic isotope effect experiments, 13C labeling experiments, time-tracking experiments, and competitive experiments, as well as DFT calculation studies.

Rhodium(III)-catalyzed C-H activation/annulation with vinyl esters as an acetylene equivalent

The behavior of electron-rich alkenes in rhodium-catalyzed C-H activation/annulation reactions is investigated. Vinyl acetate emerges as a convenient acetylene equivalent, facilitating the synthesis of sixteen 3,4-unsubstituted isoquinolones, as well as select heteroaryl-fused pyridones. The complementary regiochemical preferences of enol ethers versus enol esters/enamides is discussed.