1-Pyridin-3-ylMethyl-piperazine dihydrochloride

Base Information

• Chemical Name: 1-Pyridin-3-ylMethyl-piperazine dihydrochloride
• CAS No.: 1158392-64-3
• Molecular Formula: C10H17Cl2N3
• Molecular Weight: 250.17
• Hs Code.: 2933990090
• Mol file: 1158392-64-3.mol

Synonyms:1-Pyridin-3-ylmethylpiperazine dihydrochloride;

Chemical Property of 1-Pyridin-3-ylMethyl-piperazine dihydrochloride

Chemical Property:

• PSA: 28.16000
• LogP: 2.35750
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99.3% ^*data from raw suppliers

1-(Pyridin-3-ylmethyl)piperazinedihydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Pyridin-3-ylMethyl-piperazine dihydrochloride

There total 3 articles about 1-Pyridin-3-ylMethyl-piperazine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

tert-butyl 4-(pyridin-3-ylmethyl)piperazine-1-carboxylate (150812-36-5) → 1-pyridin-3-ylmethyl-piperazine, hydrochloride (510725-49-2,1158392-64-3,333992-77-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 4h;

Reference yield: 62.0%

piperazine (110-85-0) + nicotinyl chloride (3099-31-8) → N-(pyridin-3-ylmethyl)-piperazine trihydrochloride (1158392-64-3,333992-77-1)

Guidance literature:

piperazine; nicotinyl chloride; With potassium hydroxide; cetyltrimethylammonim bromide; In water; benzene; at 70 ℃; for 1 - 3h; Heating / reflux;

With hydrogenchloride; In ethanol; pH=3;

Reference yield:

3-pyridinecarboxaldehyde (500-22-1) → 1-pyridin-3-ylmethyl-piperazine, hydrochloride (510725-49-2,1158392-64-3,333992-77-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloromethane / 1 h / 20 °C / Inert atmosphere

1.2: 20 h / 20 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

With hydrogenchloride; In 1,4-dioxane; dichloromethane;

upstream raw materials:

piperazine

nicotinyl chloride

tert-butyl 4-(pyridin-3-ylmethyl)piperazine-1-carboxylate

3-pyridinecarboxaldehyde

Refernces

• 1、 -. "Aralkyl-alcohol peiperazine derivatives adn their uses as antidepressant". Page/Page column 7. . Retrieved 2008/06/13.