3099-31-8Relevant articles and documents
Improved Electrocatalytic CO2 Reduction with Palladium bis(NHC) Pincer Complexes Bearing Cationic Side Chains
Deluca, Emile E.,Xu, Zhen,Lam, Jasper,Wolf, Michael O.
supporting information, p. 1330 - 1343 (2019/03/28)
Stabilizing interactions between charged electrocatalytic intermediates and a series of cationic residues were explored through the synthesis and characterization of six palladium bis(N-heterocyclic carbene) (NHC) complexes bearing unique onium functionalities. The presence of a positively charged, pendant substituent was found to mediate electrode kinetics and facilitate CO2 coordination to the catalytic center in a systematic fashion. The introduction of cationic moieties into this system is shown to enhance catalytic selectivity for the conversion of CO2 to CO by as much as 5 times that of an alkyl-bearing analog. A combination of electrochemical experiments and computational analysis demonstrates that catalyst performance benefits most from a bulky onium unit tethered to the catalyst through a flexible linker. This behavior was interpreted as a preference for a wide, hydrophobic reaction pocket that allows for the unhindered formation of catalytic intermediates and mediated interaction with the solution.
A 2 - chloro -5 - nitrapyrin preparation method
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Paragraph 0031-0032, (2019/03/15)
The invention discloses a 2 - chloro - 5 - trichloromethyl pyridine method, comprises the following steps: (1) the 3 - methyl pyridine is mixed with a solvent, the vaporization of the drops in the vaporization vessel, then in order to inert gas as a carrier gas, to form raw material steam; (2) dry Cl respectively2 The raw material and the steam is sent to the quartz tube catalyst [...] generating vapor phase chlorination reaction, reaction material after the condensation, rectification to obtain 2 - chloro - 5 - trichloromethyl pyridine. The invention relates to a 2 - chloro - 5 - trichloromethyl pyridine method, with raw materials are easy, low cost, easy to operate, simple process and the like.
Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker
Wang, Heng-Yen,Qin, Yajuan,Li, Huiying,Roman, Linda J.,Martásek, Pavel,Poulos, Thomas L.,Silverman, Richard B.
supporting information, p. 4913 - 4925 (2016/06/13)
Neuronal nitric oxide synthase (nNOS) is an important therapeutic target for the treatment of various neurodegenerative disorders. A major challenge in the design of nNOS inhibitors focuses on potency in humans and selectivity over other NOS isoforms. Here we report potent and selective human nNOS inhibitors based on the 2-aminopyridine scaffold with a central pyridine linker. Compound 14j, the most promising inhibitor in this study, exhibits excellent potency for rat nNOS (Ki = 16 nM) with 828-fold n/e and 118-fold n/i selectivity with a Ki value of 13 nM against human nNOS with 1761-fold human n/e selectivity. Compound 14j also displayed good metabolic stability in human liver microsomes, low plasma protein binding, and minimal binding to cytochromes P450 (CYPs), although it had little to no Caco-2 permeability.
