3-fluoropicolinimidamide hydrochloride

Base Information

• Chemical Name: 3-fluoropicolinimidamide hydrochloride
• CAS No.: 246872-67-3
• Molecular Formula: C6H7ClFN3
• Molecular Weight: 175.5912832
• Mol file: 246872-67-3.mol

Synonyms:2-amidino-3-fluoropyridine hydrochloride;3-fluoropicolinimidamide hydrochloride;

Chemical Property of 3-fluoropicolinimidamide hydrochloride

Chemical Property:

• PSA: 62.76000
• LogP: 2.10680
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

3-fluoropicolinimidamidehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-fluoropicolinimidamide hydrochloride

There total 1 articles about 3-fluoropicolinimidamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-fluoropicolinonitrile (97509-75-6) → 3-fluoropicolinimidamide hydrochloride (246872-67-3)

Guidance literature:

3-fluoropicolinonitrile; With sodium methylate; In methanol; at 20 ℃; for 72h;

With ammonium chloride; acetic acid; at 40 ℃; for 28h;

Reference yield: 5.0%

methyl 3-(2-chloro-4-fluorophenyl)-2-[3-(4-pyridinyl)-propanoyl]-2-propenoate (361204-31-1) + 3-fluoropicolinimidamide hydrochloride (246872-67-3) → methyl 4-(2-chloro-4-fluorophenyl)-2-(3-fluoro-2-pyridinyl)-6-[2-(4-pyridinyl)-ethyl]-1,4-dihydropyrimidine-5-carboxylate (361204-34-4)

Guidance literature:

With sodium acetate; In isopropyl alcohol; Heating / reflux;

Reference yield:

3-fluoropicolinimidamide hydrochloride (246872-67-3) + 2-chloro-4-fluorobenzaldehyde (84194-36-5) + 1,3-cylohexanedione (504-02-9) → 2-(3-fluoropyridin-2-yl)-4-(2-chloro-4-fluorophenyl)-4,6,7,8-tetrahydroquinazolin-5(1H)-one (1040735-97-4)

Guidance literature:

With sodium acetate; In ethanol; for 20h; Reflux;

DOI:10.1016/j.bmcl.2009.10.119

upstream raw materials:

3-fluoropicolinonitrile

Downstream raw materials:

methyl 4-(2-chloro-4-fluorophenyl)-2-(3-fluoro-2-pyridinyl)-6-[2-(4-pyridinyl)-ethyl]-1,4-dihydropyrimidine-5-carboxylate

2-(3-fluoropyridin-2-yl)-4-(2-chloro-4-fluorophenyl)-4,6,7,8-tetrahydroquinazolin-5(1H)-one

2-(3-fluoropyridin-2-yl)-4-(2-chloro-4-fluorophenyl)-7,7-dimethyl-4,6,7,8-tetrahydroquinazolin-5(1H)-one

Refernces

• 1、 Zhu, Xuejun,Zhao, Guoming,Zhou, Xiaoping,Xu, Xiaoqian,Xia, Guangqiang,Zheng, Zhibing,Wang, Lili,Yang, Xiaohong,Li, Song. "2,4-Diaryl-4,6,7,8-tetrahydroquinazolin-5(1H)-one derivatives as anti-HBV agents targeting at capsid assembly". scheme or table. p. 299 - 301. Retrieved 2010/04/05.