3-Ethynyl-5-methylpyridin-2-amine

Base Information

• Chemical Name: 3-Ethynyl-5-methylpyridin-2-amine
• CAS No.: 863479-77-0
• Molecular Formula: C8H8N2
• Molecular Weight: 132.16
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID20459334
• Nikkaji Number: J2.865.914H
• Wikidata: Q82283078
• Mol file: 863479-77-0.mol

Synonyms:3-ethynyl-5-methylpyridin-2-amine;863479-77-0;SCHEMBL4877753;DTXSID20459334;HEESMXQXYWSDFF-UHFFFAOYSA-N;3-Ethynyl-5-methylpyridine-2-amine;AKOS006341418;AS-0697;E77255;EN300-4261247

Chemical Property of 3-Ethynyl-5-methylpyridin-2-amine

Chemical Property:

• PSA: 38.91000
• LogP: 1.53470
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 132.068748264
• Heavy Atom Count: 10
• Complexity: 156

Purity/Quality:

3-ethynyl-5-methyl-2-Pyridinamine 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(N=C1)N)C#C

Technology Process of 3-Ethynyl-5-methylpyridin-2-amine

There total 2 articles about 3-Ethynyl-5-methylpyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-methyl-3-[2-(trimethylsilyl)ethynyl]pyridin-2-ylamine (500903-95-7) → 2-amino-5-methyl-3-ethynylpyridine (863479-77-0)

Guidance literature:

With water; sodium hydroxide; In methanol; at 20 ℃;

DOI:10.1016/j.tet.2010.06.083

Reference yield:

2-amino-3-iodo-5-methylpyridine (211308-79-1) → 2-amino-5-methyl-3-ethynylpyridine (863479-77-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,4-diaza-bicyclo[2.2.2]octane / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 110 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; tetrabutyl ammonium fluoride; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield: 98.0%

2-amino-5-methyl-3-ethynylpyridine (863479-77-0) → 5-methyl-1H-pyrrolo[2,3-b]pyridine (824-52-2)

Guidance literature:

With potassium chloride; In water; at 200 ℃; for 0.5h; Microwave irradiation;

DOI:10.1016/j.tet.2010.06.083

upstream raw materials:

5-methyl-3-[2-(trimethylsilyl)ethynyl]pyridin-2-ylamine

2-amino-3-iodo-5-methylpyridine

Downstream raw materials:

5-methyl-1H-pyrrolo[2,3-b]pyridine