5-fluoro-6-Methyl-2-Pyridinecarbonitrile

Base Information

• Chemical Name: 5-fluoro-6-Methyl-2-Pyridinecarbonitrile
• CAS No.: 915720-64-8
• Molecular Formula: C7H5FN2
• Molecular Weight: 136.129
• Mol file: 915720-64-8.mol

Synonyms:5-Fluoro-6-methylpicolinonitrile;

Chemical Property of 5-fluoro-6-Methyl-2-Pyridinecarbonitrile

Chemical Property:

• PSA: 36.68000
• LogP: 1.40078
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

95% ^*data from raw suppliers

5-Fluoro-6-methylpicolinonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-fluoro-6-Methyl-2-Pyridinecarbonitrile

There total 1 articles about 5-fluoro-6-Methyl-2-Pyridinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2-bromo-5-fluoro-6-methyl-2-pyridine (374633-38-2) + dicyanozinc (557-21-1) → 5-fluoro-6-methylpicolinonitrile (915720-64-8)

Guidance literature:

With zinc; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In ISOPROPYLAMIDE; at 20 - 100 ℃; Heating / reflux;

Reference yield: 84.0%

5-fluoro-6-methylpicolinonitrile (915720-64-8) + 4-chloro-phenol (106-48-9,82344-39-6) → 5-(4-chlorophenoxy)-6-methylpicolinonitrile

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 16h;

Reference yield:

5-fluoro-6-methylpicolinonitrile (915720-64-8) → C21H19F4N5OS

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / dimethyl sulfoxide / 1 h / 80 - 120 °C

2: hydrogenchloride / 0 - 20 °C

3: acetonitrile / 32 h / 50 °C

With hydrogenchloride; potassium carbonate; In dimethyl sulfoxide; acetonitrile;

DOI:10.1016/j.bmcl.2014.10.024

upstream raw materials:

2-bromo-5-fluoro-6-methyl-2-pyridine

dicyanozinc

Downstream raw materials:

1-(5-fluoro-6-methylpyridin-2-yl)ethan-1-one

N-[2-fluoro-5-(trifluoromethyl)phenyl]-1-methyl-3-[6-methyl-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]-1H-1,2,4-triazol-5-amine

1-(5-fluoro-6-methylpyridin-2-yl)ethanol

6-(1-azidoethyl)-3-fluoro-2-methylpyridine

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