3a,4,5,6-tetrahydro-3-oxo-3H-Pyrrolo[1,2-c][1,2,3]oxadiazol-7- iuM inner salt

Base Information

• Chemical Name: 3a,4,5,6-tetrahydro-3-oxo-3H-Pyrrolo[1,2-c][1,2,3]oxadiazol-7- iuM inner salt
• CAS No.: 98262-66-9
• Molecular Formula: C₅H₆N₂O₂
• Molecular Weight: 126.115
• Hs Code.: 2934999090
• Mol file: 98262-66-9.mol

Synonyms:3a,4,5,6-tetrahydro-3-oxo-3H-pyrrolo[1,2-c][1,2,3]oxadiazol-7-ium ylide;5,6-dihydro-4H-pyrrolo[1,2-c][1,2,3]oxadiazol-7-ium-3-olate;3,4-cyclopenta[c]sydnone;

Chemical Property of 3a,4,5,6-tetrahydro-3-oxo-3H-Pyrrolo[1,2-c][1,2,3]oxadiazol-7- iuM inner salt

Chemical Property:

• PSA: 48.03000
• LogP: -0.21750

Purity/Quality:

99% ^*data from raw suppliers

3a,4,5,6-tetrahydro-3-oxo-3H-Pyrrolo[1,2-c][1,2,3]oxadiazol-7-iuminnersalt 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3a,4,5,6-tetrahydro-3-oxo-3H-Pyrrolo[1,2-c][1,2,3]oxadiazol-7- iuM inner salt

There total 8 articles about 3a,4,5,6-tetrahydro-3-oxo-3H-Pyrrolo[1,2-c][1,2,3]oxadiazol-7- iuM inner salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

nitrosoproline (7519-36-0) → 3a,4,5,6-tetrahydro-3-oxo-3H-pyrrolo[1,2-c][1,2,3]oxadiazol-7-ium ylide (98262-66-9,86477-05-6)

Guidance literature:

With trifluoroacetic anhydride; In dichloromethane; at 5 ℃; for 0.5h;

Reference yield: 100.0%

N-nitroso-D-proline (42022-03-7) → 3a,4,5,6-tetrahydro-3-oxo-3H-pyrrolo[1,2-c][1,2,3]oxadiazol-7-ium ylide (98262-66-9,86477-05-6)

Guidance literature:

With trifluoromethylsulfonic anhydride; In dichloromethane; at 5 ℃; for 0.5h;

Reference yield: 93.7%

N-nitrosoproline (55514-92-6,55514-93-7,2571-28-0) → 3a,4,5,6-tetrahydro-3-oxo-3H-pyrrolo[1,2-c][1,2,3]oxadiazol-7-ium ylide (98262-66-9,86477-05-6)

Guidance literature:

With trifluoroacetic anhydride; In toluene; at 15 ℃; for 1h;

upstream raw materials:

N-nitrosoproline

nitrosoproline

L-proline

1-Nitro-prolin

Downstream raw materials:

5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-3-carboxylic acid ethyl ester

ethyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate

2-n-butyl-3-(p-toluenesulfonyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole

2-n-butyl-3-[p-(hydroxymethyl)benzenesulfonyl]-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole

Refernces

• 1、 -. "MACROCYCLIC FUSED PYRRAZOLES AS MCL-1 INHIBITORS". Paragraph 0882. . Retrieved 2020/08/13.
• 2、 -. "Big ring indole used as MCL-1 inhibitor". . . Retrieved 2020/03/12.