42022-03-7

Basic information

• Product Name: N-NITROSO-D-PROLINE
• Synonyms: N-NITROSO-D-PROLINE;1-Nitroso-D-proline
• CAS NO: 42022-03-7
• Molecular Formula: C5H8N2O3
• Molecular Weight: 144.12862
• Product Categories: Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Heterocycles;Mutagenesis Research Chemicals
• Mol File: 42022-03-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 109-110°C
• Boiling Point: 391.692°C at 760 mmHg
• Flash Point: 190.688°C
• Appearance: /
• Density: 1.572g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.629
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Methanol, Water
• CAS DataBase Reference: N-NITROSO-D-PROLINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-NITROSO-D-PROLINE(42022-03-7)
• EPA Substance Registry System: N-NITROSO-D-PROLINE(42022-03-7)

Safety Data

• Hazardous Substances Data: 42022-03-7(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Crystals

Uses

Different sources of media describe the Uses of 42022-03-7 differently. You can refer to the following data:
1. A nitrosoamino acid with oncogenicity. The LD50 of a single ip dose given to Swiss-Webster mice is 203 +/- 22 mg / kg
2. A nitrosoamino acid with oncogenic activity. The LD50 of a single ip dose given to Swiss-Webster mice is 203 +/- 22 mg / kg.

InChI:InChI=1/C5H8N2O3/c8-5(9)4-2-1-3-7(4)6-10/h4H,1-3H2,(H,8,9)/t4-/m1/s1

Upstream product

• 344-25-2 D-Prolin 
• 147-85-3 L-proline 

Downstream Products

• 98262-66-9 3a,4,5,6-tetrahydro-3-oxo-3H-pyrrolo[1,2-c][1,2,3]oxadiazol-7-ium ylide 
• 102608-17-3 N-trifluoroacetylamino-2-pyrrolidone 

Relevant articles and documents

Versatile new reagent for nitrosation under mild conditions

Here we report a new chemical reagent for transnitrosation under mild experimental conditions. This new reagent is stable to air and moisture across a broad range of temperatures and is effective for transnitrosation in multiple solvents. Compared with traditional nitrosation methods, our reagent shows high functional group tolerance for substrates that are susceptible to oxidation or reversible transnitrosation. Several challenging nitroso compounds are accessed here for the first time, including 15N isotopologues. X-ray data confirm that two rotational isomers of the reagent are configurationally stable at room temperature, although only one isomer is effective for transnitrosation. Computational analysis describes the energetics of rotamer interconversion, including interesting geometry-dependent hybridization effects.

Big ring indole used as MCL-1 inhibitor

The invention provides a compound represented by a formula (I) and a pharmaceutical salt and solvate thereof. In the formula (I), the definitions of R, R1a, R1b, R1h, L1, L2, and L3 are shown in the description. The invention also provides a compound represented by the formula (I), and the compound can be used to treat disease or disorder related with MCL-1 inhibition, such as cancers.