3-(2-acetaMido-4-(tert-butoxycarbonyloxy)naphthalen-1-yl)-2- hydroxypropyl Methanesulfonate

Base Information

Chemical Name:3-(2-acetaMido-4-(tert-butoxycarbonyloxy)naphthalen-1-yl)-2- hydroxypropyl Methanesulfonate
CAS No.:144191-96-8
Molecular Formula:C21H27NO8S
Molecular Weight:453.50598
Hs Code.:
Mol file:144191-96-8.mol

Synonyms:Methanesulfonic acid 3-(2-acetylamino-4-tert-butoxycarbonyloxy-naphthalen-1-yl)-2-hydroxy-propyl ester;

Suppliers and Price of 3-(2-acetaMido-4-(tert-butoxycarbonyloxy)naphthalen-1-yl)-2- hydroxypropyl Methanesulfonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AccelPharmtech
3-(2-acetamido-4-(tert-butoxycarbonyloxy)naphthalen-1-yl)-2-hydroxypropylmethanesulfonate 97.00%
25G
$ 9110.00

AccelPharmtech
3-(2-acetamido-4-(tert-butoxycarbonyloxy)naphthalen-1-yl)-2-hydroxypropylmethanesulfonate 97.00%
5G
$ 4850.00

AccelPharmtech
3-(2-acetamido-4-(tert-butoxycarbonyloxy)naphthalen-1-yl)-2-hydroxypropylmethanesulfonate 97.00%
1G
$ 2820.00

Total 1 raw suppliers

Chemical Property of 3-(2-acetaMido-4-(tert-butoxycarbonyloxy)naphthalen-1-yl)-2- hydroxypropyl Methanesulfonate

Chemical Property:

PSA：136.61000
LogP:4.14550

Purity/Quality:: 3-(2-acetamido-4-(tert-butoxycarbonyloxy)naphthalen-1-yl)-2-hydroxypropylmethanesulfonate 97.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 3-(2-acetaMido-4-(tert-butoxycarbonyloxy)naphthalen-1-yl)-2- hydroxypropyl Methanesulfonate

There total 8 articles about 3-(2-acetaMido-4-(tert-butoxycarbonyloxy)naphthalen-1-yl)-2- hydroxypropyl Methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 124-63-0
methanesulfonyl chloride

: 144191-95-7
1,2-dihydroxy-3-<2-(aminoacetyl)-4-<<(tert-butyloxy)carbonyl>oxy>naphthalen-1-yl>propane

: 144191-96-8
1-<(methylsulfonyl)oxy>-2-hydroxy-3-<2-(benzylamino)-4-<<(tert-butyloxy)carbonyl>oxy>naphthalen-1-yl>propane

Guidance literature:: With pyridine; dmap; at 5 ℃; for 18h;
DOI:10.1021/jo00049a035

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 144191-96-8
1-<(methylsulfonyl)oxy>-2-hydroxy-3-<2-(benzylamino)-4-<<(tert-butyloxy)carbonyl>oxy>naphthalen-1-yl>propane

Guidance literature:: Multi-step reaction with 5 steps

1: 1) 4-dimethylaminopyridine, 2) Na₂S₂O₄ / 1) CH₃CN, 18 h, RT, 2) H₂O, EtOAc, 24 h, RT

2: 84 percent / N-methylmorpholine N-oxide, OsO₄ / acetone; H₂O / 18 h / Ambient temperature

3: formic acid / 10percent Pd-C / methanol / 0.5 h / Ambient temperature

4: pyridine / 1 h

5: 75 percent / 4-dimethylaminopyridine, pyridine / 18 h / 5 °C

With pyridine; dmap; osmium(VIII) oxide; formic acid; sodium dithionite; 4-methylmorpholine N-oxide; palladium on activated charcoal; In methanol; water; acetone;
DOI:10.1021/jo00049a035

Reference yield:

: 24137-17-5
2-benzylamino-[1,4]naphthoquinone

: 144191-96-8
1-<(methylsulfonyl)oxy>-2-hydroxy-3-<2-(benzylamino)-4-<<(tert-butyloxy)carbonyl>oxy>naphthalen-1-yl>propane

Guidance literature:: Multi-step reaction with 6 steps

1: 75 percent / tetrahydrofuran; diethyl ether / 1 h / 5 °C

2: 1) 4-dimethylaminopyridine, 2) Na₂S₂O₄ / 1) CH₃CN, 18 h, RT, 2) H₂O, EtOAc, 24 h, RT

3: 84 percent / N-methylmorpholine N-oxide, OsO₄ / acetone; H₂O / 18 h / Ambient temperature

4: formic acid / 10percent Pd-C / methanol / 0.5 h / Ambient temperature

5: pyridine / 1 h

6: 75 percent / 4-dimethylaminopyridine, pyridine / 18 h / 5 °C

With pyridine; dmap; osmium(VIII) oxide; formic acid; sodium dithionite; 4-methylmorpholine N-oxide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; water; acetone;
DOI:10.1021/jo00049a035