1-Boc-3-(cyanomethylene)azetidine

Base Information

Chemical Name:1-Boc-3-(cyanomethylene)azetidine
CAS No.:1153949-11-1
Molecular Formula:C10H14N2O2
Molecular Weight:194.233
Hs Code.:2933990090
Mol file:1153949-11-1.mol

Synonyms:3-(Cyanomethylene)-1-azetidinecarboxylic acid tert-butyl ester; 2-Methyl-2-propanyl 3-(cyanomethylene)-1-azetidinecarboxylate; 1-Boc-3-(cyanomethylene)azetidine; 3-Cyanomethylene-azetidine-1-carboxylic acid tert-butyl ester; tert-butyl 3-(cyanoMethylidene)azetidine-1-carboxylate; P-Hydroxy phenyl butanone (Raspberry ketone); tert-butyl-3-(cyanomethylene)azetidine-1-carboxylate

Suppliers and Price of 1-Boc-3-(cyanomethylene)azetidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine
1g
$ 45.00

TRC
1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine
25g
$ 340.00

TCI Chemical
1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine >95.0%(GC)
1g
$ 152.00

TCI Chemical
1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine >95.0%(GC)
200mg
$ 54.00

Synthonix
1-Boc-3-(cyanomethylene)azetidine 95+%
1g
$ 15.00

Matrix Scientific
1-Boc-3-(cyanomethylene)azetidine 95+%
1g
$ 479.00

Crysdot
tert-Butyl3-(cyanomethylene)azetidine-1-carboxylate 98%
10g
$ 77.00

Chem-Impex
1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine,≥95%(GC)Hazmat ≥95%(GC)
1G
$ 172.18

Chem-Impex
1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine,≥95%(GC)Hazmat ≥95%(GC)
200MG
$ 53.15

Chemenu
tert-butyl3-(cyanomethylidene)azetidine-1-carboxylate 95+%
100g
$ 214.00

Total 75 raw suppliers

Chemical Property of 1-Boc-3-(cyanomethylene)azetidine

Chemical Property:

Boiling Point:309.7±35.0 °C(Predicted)
PKA:-1.88±0.20(Predicted)
PSA：53.33000
Density:1.215
LogP:1.62498
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine is used in the synthesis of baricitinib via Horner-Emmons reaction of tert-butyl-oxoazetidine-carboxylate followed by sulfonamidation, nucleophilic addition. and subsequent Suzuki-coupling reaction.

Technology Process of 1-Boc-3-(cyanomethylene)azetidine

There total 6 articles about 1-Boc-3-(cyanomethylene)azetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 398489-26-4
tert-butyl 3-oxoazetidine-1-carboxylate

: 2537-48-6
diethyl 1-cyanomethylphosphonate

: 1153949-11-1
3-(cyanomethylene)azetidine-1-carboxylic acid tert-butyl ester

Guidance literature:: diethyl 1-cyanomethylphosphonate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃;

tert-butyl 3-oxoazetidine-1-carboxylate; In tetrahydrofuran; mineral oil; Product distribution / selectivity;

Reference yield: 91.0%

: 398489-26-4
tert-butyl 3-oxoazetidine-1-carboxylate

: 50586-62-4
diethyl cyanomethyl phosphonate

: 1153949-11-1
3-(cyanomethylene)azetidine-1-carboxylic acid tert-butyl ester

Guidance literature:: diethyl cyanomethyl phosphonate; With potassium tert-butylate; In tetrahydrofuran; at -15 - -5 ℃; for 3h; Inert atmosphere;

tert-butyl 3-oxoazetidine-1-carboxylate; In tetrahydrofuran; for 18h; Inert atmosphere;

Reference yield: 72.0%

: 398489-26-4
tert-butyl 3-oxoazetidine-1-carboxylate

: C₈H₁₆NO₅P

: 1153949-11-1
3-(cyanomethylene)azetidine-1-carboxylic acid tert-butyl ester

Guidance literature:: C₈H₁₆NO₅P; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 1h;

tert-butyl 3-oxoazetidine-1-carboxylate; In tetrahydrofuran; mineral oil; for 0.5h;
DOI:10.1039/c9cc06446j