INCB39110

Base Information

Chemical Name:INCB39110
CAS No.:1334302-63-4
Molecular Formula:
Molecular Weight:0
Hs Code.:

Synonyms:INCB39110;2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl)piperidin-4-yl)azetidin-3-yl)acetonitrile INCB39110

Suppliers and Price of INCB39110

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of INCB39110

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of INCB39110

There total 25 articles about INCB39110 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.6%

: 124-04-9
Adipic acid

: 1334298-90-6
2-(1-{1-[3-fluoro-2-(trifluoromethyl)pyridine-4-carbonyl]piperidin-4-yl}-3-(4-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile

: 1334302-63-4
2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl)piperidin-4-yl)azetidin-3-yl)acetonitrile adipate

Guidance literature:: In acetone; Inert atmosphere; Reflux;

Reference yield:

: 124-04-9
Adipic acid

: 142-82-5
n-heptane

: 1334298-90-6
2-(1-{1-[3-fluoro-2-(trifluoromethyl)pyridine-4-carbonyl]piperidin-4-yl}-3-(4-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile

: 1334302-63-4
2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl)piperidin-4-yl)azetidin-3-yl)acetonitrile adipate

Guidance literature:: With nitrogen;

Reference yield:

: 1153949-11-1
3-(cyanomethylene)azetidine-1-carboxylic acid tert-butyl ester

: 1334302-63-4
2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl)piperidin-4-yl)azetidin-3-yl)acetonitrile adipate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 3.4 h / 10 - 20 °C / Large scale

2.1: hydrogenchloride / methanol; isopropyl alcohol / 2 h / 40 °C

3.1: triethylamine / dichloromethane / 0.17 h / 15 - 30 °C / Large scale

3.2: 2 h / 15 - 30 °C / Large scale

4.1: boron trifluoride diethyl etherate / acetonitrile / 23 h / 5 - 20 °C

4.2: 2 h / 5 - 20 °C

4.3: 20 h / 5 - 20 °C

5.1: methanol / 2 h / Reflux

With hydrogenchloride; boron trifluoride diethyl etherate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In methanol; dichloromethane; isopropyl alcohol; acetonitrile;