7-Deaza-2'-deoxy-7-iodoadenosine

Base Information

• Chemical Name: 7-Deaza-2'-deoxy-7-iodoadenosine
• CAS No.: 908130-61-0
• Molecular Formula: C₁₁H₁₃IN₄O₃
• Molecular Weight: 376.154
• Mol file: 908130-61-0.mol

Synonyms:7-Deaza-2'-deoxy-7-iodoadenosine;7-Deaza-21-deoxy-7-iodoadenosine;(2S,3R,5S)-7-Deaza-2'-deoxy-7-iodoadenosine;7-(2-Deoxy-β-L-erythro-pentofuranosyl)-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-4-amine;7-(2-deoxy-β-L-erythro-pentofuranosyl)-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-4-amine;7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-(2-deoxy-β-L-erythro-pentofuranosyl)-5-iodo-;7-(2-Deoxy-beta-L-erythro-pentofuranosyl)-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-4-amine;(2S,3R,5S)-5-(4-amino-5-iodopyrrolo[2,3-d]pyrimidin-7-yl)-2-(hydroxymethyl)oxolan-3-ol;(2S,3R,5S)-5-(4-AMino-5-iodo-7H-pyrrolo[2,3-d]pyriMidin-7-yl)-2-(hydroxyMethyl)tetrahydrofuran-3-ol

Chemical Property of 7-Deaza-2'-deoxy-7-iodoadenosine

Chemical Property:

• PSA: 106.42000
• LogP: 0.84000

Purity/Quality:

99% ^*data from raw suppliers

(2S,3R,5S)-5-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Deaza-2'-deoxy-7-iodoadenosine

There total 11 articles about 7-Deaza-2'-deoxy-7-iodoadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-chloro-7-(2-deoxy-β-L-erythro-pentofuranosyl)-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (933995-40-5) → β-L-2'-deoxy-7-iodotubercidin (908130-61-0)

Guidance literature:

With ammonium hydroxide; In 1,4-dioxane; at 110 ℃; for 17h;

DOI:10.1135/cccc20060956

Reference yield: 80.0%

(2R,3S,5R)-5-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-((4-chlorobenzoyloxy)methyl)tetrahydrofuran-3-yl 4-chlorobenzoate → 7-deaza-2'-deoxy-7-iodoadenosine (166247-63-8,908130-61-0)

Guidance literature:

(2R,3S,5R)-5-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-((4-chlorobenzoyloxy)methyl)tetrahydrofuran-3-yl 4-chlorobenzoate; With ammonia; In methanol; at 0 - 100 ℃; for 0.5h;

In methanol; at 100 ℃; for 24h; Sealed tube;

DOI:10.1139/cjc-2018-0303

Reference yield: 70.0%

9-(β-D-2'-deoxyribofuranosyl)-6-chloro-7-iodo-7-deazapurine (178995-71-6) → 7-deaza-2'-deoxy-7-iodoadenosine (166247-63-8,908130-61-0)

Guidance literature:

With ammonium hydroxide; In 1,4-dioxane; at 110 ℃; for 15h;

DOI:10.1055/s-1996-4282

upstream raw materials:

9-(β-D-2'-deoxyribofuranosyl)-6-chloro-7-iodo-7-deazapurine

(2R,3S,5R)-5-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-methylbenzoate

4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine

2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride