Technology Process of (2R,3S,5R)-5-(4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol
There total 1 articles about (2R,3S,5R)-5-(4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine;
With
potassium hydroxide; Tris(3,6-dioxaheptyl)amine;
In
acetonitrile;
at 20 ℃;
for 0.166667h;
2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride;
In
acetonitrile;
at 20 ℃;
for 1h;
With
ammonia;
In
methanol;
at 20 ℃;
for 24h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C
2: bis(benzonitrile)palladium(II) dichloride; triethylamine / 1,4-dioxane / 48 h / 50 °C
3: lithium borohydride / tetrahydrofuran; methanol / 0.92 h / 20 °C / Reflux
4: tetrabutylammomium bromide; sodium hydroxide / dichloromethane / 48 h / 20 °C / Darkness
With
1H-imidazole; bis(benzonitrile)palladium(II) dichloride; lithium borohydride; tetrabutylammomium bromide; triethylamine; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/anie.201106516
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C
2: bis(benzonitrile)palladium(II) dichloride; triethylamine / 1,4-dioxane / 48 h / 50 °C
3: lithium borohydride / tetrahydrofuran; methanol / 0.92 h / 20 °C / Reflux
4: tetrabutylammomium bromide; sodium hydroxide / dichloromethane / 48 h / 20 °C / Darkness
5: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C
6: ammonia / 1,4-dioxane; methanol / 16 h / 100 °C
With
1H-imidazole; bis(benzonitrile)palladium(II) dichloride; lithium borohydride; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; ammonia; triethylamine; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/anie.201106516
