3,4-difluoro-2,6-diiodophenol

Base Information

• Chemical Name: 3,4-difluoro-2,6-diiodophenol
• CAS No.: 1228093-47-7
• Molecular Formula: C6H2F2I2O
• Molecular Weight: 381.887
• Mol file: 1228093-47-7.mol

Synonyms:3,4-difluoro-2,6-diiodo-phenol;

Chemical Property of 3,4-difluoro-2,6-diiodophenol

Chemical Property:

• Melting Point: 86 °C
• Boiling Point: 228.2±35.0 °C(Predicted)
• PKA: 6.10±0.28(Predicted)
• PSA: 20.23000
• Density: 2.719±0.06 g/cm3(Predicted)
• LogP: 2.87960
• Storage Temp.: 2-8°C

Purity/Quality:

3,4-Difluoro-2,6-diiodo-phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-difluoro-2,6-diiodophenol

There total 1 articles about 3,4-difluoro-2,6-diiodophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3,4-difluorophenol (2713-33-9) → 3,4-difluoro-2,6-diiodophenol (1228093-47-7)

Guidance literature:

With iodine; sodium hydrogencarbonate; In water; at 20 ℃; for 24h; Temperature;

DOI:10.1016/j.jfluchem.2019.109371

Reference yield: 85.0%

3,4-difluoro-2,6-diiodophenol (1228093-47-7) + tris-iso-propylsilyl acetylene (89343-06-6) → 3,4-difluoro-2,6-bis((triisopropylsilyl)ethynyl)phenol

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In acetonitrile; at 20 ℃; for 48h; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.jfluchem.2019.109435

Reference yield: 80.0%

3,4-difluoro-2,6-diiodophenol (1228093-47-7) + phenylacetylene (536-74-3) → 5,6-difluoro-2-phenyl-7-(phenylethynyl)benzofuran

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In acetonitrile; at 20 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.jfluchem.2019.109371

upstream raw materials:

3,4-difluorophenol

Downstream raw materials:

3,4-difluoro-2,6-diiodoanisole

Refernces

• 1、 Francke, Robert,Schnakenburg, Gregor,Waldvogel, Siegfried R.. "Efficient and reliable iodination and o-Methylation of fluorinated phenols". experimental part. p. 2357 - 2362. Retrieved 2010/07/04.