2713-33-9

Usage

Uses

Used in Liquid Crystal Industry:
3,4-Difluorophenol is used as an intermediate for the synthesis of liquid crystals. Its unique chemical structure and properties make it a valuable component in the development of advanced liquid crystal materials with specific characteristics, such as improved stability, enhanced electro-optical properties, and increased temperature range.
Used in Pharmaceutical Industry:
3,4-Difluorophenol can be used as a building block for the synthesis of various pharmaceutical compounds. Its fluorinated structure may provide improved bioavailability, metabolic stability, and target selectivity for drug candidates, leading to more effective treatments for various diseases.
Used in Chemical Research:
As a versatile organic compound, 3,4-difluorophenol can be employed in chemical research for the development of new synthetic methods, understanding reaction mechanisms, and exploring the effects of fluorination on molecular properties. This can contribute to the advancement of organic chemistry and the discovery of novel compounds with potential applications in various fields.
Used in Material Science:
The unique properties of 3,4-difluorophenol, such as its low melting point and fluorinated structure, make it a candidate for the development of new materials with specific characteristics. These materials could have applications in areas such as coatings, adhesives, and polymers, where improved performance and durability are desired.

InChI:InChI=1/C6H4F2O/c7-5-2-1-4(9)3-6(5)8/h1-3,9H

Upstream product

• 3863-11-4 3,4-difluoroaniline 
• 367-11-3 ortho-difluorobenzene 
• 1188330-33-7 C₁₄H₁₅F₄NO₆ 
• 1188330-43-9 C₁₄H₁₄F₅NO₆ 
• 1200828-99-4 C₁₇H₂₃F₂NO₆ 
• 168267-41-2 (3,4-difluorophenyl)boronic acid 
• 1188330-26-8 C₁₄H₁₆F₃NO₆ 
• 1188330-19-9 C₁₄H₁₇F₂NO₆ 
• 34036-07-2 3,4 difluorobenzaldehyde 
• 369-34-6 3,4-difluoronitrobenzene 

Downstream Products

• 94737-80-1 4-Propyl-cyclohexanecarboxylic acid 3,4-difluoro-phenyl ester 
• 135136-25-3 Cyclopropyl-[4-(3,4-difluoro-phenoxymethyl)-piperidin-1-yl]-methanone 
• 170876-51-4 1-(3,4-difluorophenoxy)-2,3-epoxypropane 
• 486449-90-5 4-(3,4-difluorophenoxy)benzaldehyde 
• 163848-46-2 3,4-difluorophenyl ethyl ether 
• 115144-40-6 1,2-difluoro-4-methoxy-benzene 
• 708276-49-7 2-(3,4-difluorophenoxy)-1-(4-methylsulfanylphenyl)ethanone 
• 749230-28-2 (3,4-difluorophenoxy)triisopropylsilane 
• 749230-22-6 1,2-difluoro-4-(methoxymethoxy)benzene 

Relevant academic research and scientific papers

Cellulose as recyclable organocatalyst for ipso-hydroxylation of arylboronic acids

Cellulose catalyzed oxidative hydroxylation of aryl and hetero-arylboronic acids to the corresponding phenols under metal and base free strategy has been demonstrated. The sustainable ipso-hydroxylation takes place using hydrogen peroxide as an oxidant in water under mild condition in shorter period of time. Interestingly, easy recovery and reusability of heterogeneous catalyst without significant loss in catalytic yield makes the protocol environmentally benign.

Probing synergy between two catalytic strategies in the glycoside hydrolase O-GlcNAcase using multiple linear free energy relationships

Human O-GlcNAcase plays an important role in regulating the post-translational modification of serine and threonine residues with β-O-linked N-acetylglucosamine monosaccharide unit (O-GlcNAc). The mechanism of O-GlcNAcase involves nucleophilic participation of the 2-acetamido group of the substrate to displace a glycosidically linked leaving group. The tolerance of this enzyme for variation in substrate structure has enabled us to characterize O-GlcNAcase transition states using several series of substrates to generate multiple simultaneous free-energy relationships. Patterns revealing changes in mechanism, transition state, and rate-determining step upon concomitant variation of both nucleophilic strength and leaving group abilities are observed. The observed changes in mechanism reflect the roles played by the enzymic general acid and the catalytic nucleophile. Significantly, these results illustrate how the enzyme synergistically harnesses both modes of catalysis; a feature that eludes many small molecule models of catalysis. These studies also suggest the kinetic significance of an oxocarbenium ion intermediate in the O-GlcNAcase-catalyzed hydrolysis of glucosaminides, probing the limits of what may be learned using nonatomistic investigations of enzymic transition-state structure and offering general insights into how the superfamily of retaining glycoside hydrolases act as efficient catalysts.

Enzymatic Baeyer-Villiger oxidation of benzaldehydes

The selectivity of the chemical Baeyer-Villiger oxidation of benzaldehydes depends on steric and electronic factors, the type of oxidizing agent and the reaction conditions. Here we report on the enzymatic Baeyer-Villiger oxidation of fluorobenzaldehydes

Selective and one-pot formation of phenols by anodic oxidation

Direct monohydroxylation of benzene and substituted benzenes was successfully performed by anodic oxidation to form the corresponding phenol derivatives in good yields. The anodic oxidation was generally carried out in a mixed solvent of trifluoroacetic acid and dichloromethane containing triethylamine using a divided cell equipped with a platinum plate as the anode, a carbon rod as the cathode. Benzene derivatives having electron withdrawing groups were suitable for the present electrochemical oxidation. It was clarified that aryltrifluoroacetates were formed as the initial products from the reaction of the radical cations, generated by one electron transfer from the substrates, with trifluoroacetic acid, followed by hydrolysis during work-up to give the corresponding phenols.

SYNTHESIS AND SOME PROPERTIES OF 3,4-DIFLUOROPHENYL TRANS-4 prime -SUBSTITUTED CYCLOHEXANE-1 prime -CARBOXYLATES.

A new series of 3,4-difluorophenyl trans-4 prime -substituted cyclohexane-1 prime -carboxylates was synthesized in order to achieve a nematic compound of positive dielectric anisotropy and low viscosity. The effect of fluoro substituents on mesomorphic and physical properties was established by comparing these compounds with other fluorinated nematic compounds.