5-AMINO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE

Base Information

• Chemical Name: 5-AMINO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE
• CAS No.: 41823-28-3
• Molecular Formula: C10H11NO
• Molecular Weight: 161.203
• Mol file: 41823-28-3.mol

Synonyms:5-AMINO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE;5-Amino-1,2,3,4-tetrahydronaphthalene-1-one;5-Amino-1-tetralone;5-Amino-3,4-dihydro-1(2H)-naphthalenone;5-aMino-2,3,4-trihydronaphthalen-1-one;5-AMino-3,4-dihydro-2H-naphthalen-1-one

Chemical Property of 5-AMINO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE

Chemical Property:

• Melting Point: 119-120℃
• PSA: 43.09000
• LogP: 2.36900
• Storage Temp.: 2-8°C

Purity/Quality:

97% purity ^*data from raw suppliers

5-Amino-3,4-dihydronaphthalen-1(2H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-AMINO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE

There total 13 articles about 5-AMINO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5-nitro-1-tetralone (51114-73-9) → 5-amino-3,4-dihydronaphthalen-1(2H)-one (41823-28-3)

Guidance literature:

With phenylsilane; triphenylphosphine; sodium iodide; In chloroform; at 60 ℃; for 72h; Inert atmosphere; Irradiation;

DOI:10.1021/acs.orglett.1c01654

Reference yield: 81.0%

5-nitro-1-tetralone (51114-73-9) + iron (7439-89-6) → 5-amino-3,4-dihydronaphthalen-1(2H)-one (41823-28-3)

Guidance literature:

With ammonium chloride; In methanol; water;

Reference yield: 81.0%

5-amino-1-naphthol (83-55-6) → 5-amino-3,4-dihydronaphthalen-1(2H)-one (41823-28-3)

Guidance literature:

With aluminum tri-bromide; cyclohexane; at 110 ℃; for 40h;

DOI:10.1016/S0040-4020(02)00512-4

upstream raw materials:

5-nitro-1-tetralone

6-mercapto-5-nitro-3,4-dihydro-1(2H)-naphthalenone

tetralin

5-amino-1-naphthol

Downstream raw materials:

5-chloro-3,4-dihydro-1(2H)-naphthalenone

N-benzyl-N-(5-cyano-7,8-dihydronaphthalen-1-yl)methanesulfonamide

N-benzyl-N-(5-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)methanesulfonamide

Refernces

• 1、 -. "NAPTHOQUINONES, PRO-DRUGS, AND METHODS OF USE THEREOF". Paragraph 00140. . Retrieved 2017/07/06.
• 2、 Koltunov, Konstantin Yu,Surya Prakash,Rasul, Golam,Olah, George A. "Superacid catalyzed reactions of 5-amino-1-naphthol with benzene and cyclohexane". . p. 5423 - 5426. Retrieved 2007/10/03.