2,4-Dichloro-5-ethylpyrimidine

Base Information

Chemical Name:2,4-Dichloro-5-ethylpyrimidine
CAS No.:34171-40-9
Molecular Formula:C6H6Cl2N2
Molecular Weight:177.033
Hs Code.:2933599090
DSSTox Substance ID:DTXSID50434093
Wikidata:Q72466137
Mol file:34171-40-9.mol

Synonyms:2,4-dichloro-5-ethylpyrimidine;34171-40-9;Pyrimidine, 2,4-dichloro-5-ethyl-;MFCD11040247;2,4-dichloro-5-ethyl-pyrimidine;ethyl 2,4-dichloropyrimidine;SCHEMBL4579208;DTXSID50434093;YFYFVWTWMBQHOH-UHFFFAOYSA-N;AKOS006308061;CS-W005213;SB57703;AS-19651;SY037670;2,4-dichloro-5-ethylpyrimidine, AldrichCPR;EN300-6745883;A875085;Z1198305337

Suppliers and Price of 2,4-Dichloro-5-ethylpyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2,4-Dichloro-5-ethylpyrimidine
1g
$ 525.00

TRC
2,4-Dichloro-5-ethylpyrimidine
10mg
$ 70.00

TRC
2,4-Dichloro-5-ethylpyrimidine
50mg
$ 140.00

SynQuest Laboratories
2,4-Dichloro-5-ethylpyrimidine
1 g
$ 152.00

SynQuest Laboratories
2,4-Dichloro-5-ethylpyrimidine
5 g
$ 453.00

SynQuest Laboratories
2,4-Dichloro-5-ethylpyrimidine
10 g
$ 754.00

Crysdot
2,4-Dichloro-5-ethylpyrimidine 97%
10g
$ 495.00

Crysdot
2,4-Dichloro-5-ethylpyrimidine 97%
25g
$ 941.00

Crysdot
2,4-Dichloro-5-ethylpyrimidine 97%
5g
$ 297.00

Chemenu
2,4-Dichloro-5-ethylpyrimidine 97%
10g
$ 468.00

Total 34 raw suppliers

Chemical Property of 2,4-Dichloro-5-ethylpyrimidine

Chemical Property:

Boiling Point:246℃
PKA:-2.50±0.29(Predicted)
Flash Point:126℃
PSA：25.78000
Density:1.335
LogP:2.34580
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
XLogP3:2.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:175.9908036
Heavy Atom Count:10
Complexity:110

Purity/Quality:

99%, ^*data from raw suppliers

2,4-Dichloro-5-ethylpyrimidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Statements: 41
Safety Statements: 26-39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1=CN=C(N=C1Cl)Cl
Uses 2,4-Dichloro-5-ethylpyrimidine is a reactant used for the synthesis of pyrimidine derivatives as inhibitors of dipeptidyl peptidase IV, TBK1/IKKε kinases, and as an inhibitor of a hedgehog signaling pathway.

Technology Process of 2,4-Dichloro-5-ethylpyrimidine

There total 4 articles about 2,4-Dichloro-5-ethylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 4212-49-1
5-ethyluracil

: 34171-40-9
2,4-dichloro-5-ethylpyrimidine

Guidance literature:: With N,N-dimethyl-aniline; trichlorophosphate; at 120 ℃; for 5h;

Reference yield:

: 63857-18-1
2-formyl-butyric acid methyl ester

: 34171-40-9
2,4-dichloro-5-ethylpyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran; methanol / Reflux

2: trichlorophosphate; N-ethyl-N,N-diisopropylamine / 90 °C

With N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2012.09.063