8-(Benzyloxy)-3-bromoimidazo[1,2-a]pyridine

Base Information

• Chemical Name: 8-(Benzyloxy)-3-bromoimidazo[1,2-a]pyridine
• CAS No.: 109388-59-2
• Molecular Formula: C14H11BrN2O
• Molecular Weight: 303.158
• Hs Code.: 2933990090
• European Community (EC) Number: 937-668-6
• DSSTox Substance ID: DTXSID70546561
• Wikidata: Q82424429
• Mol file: 109388-59-2.mol

Synonyms:8-(benzyloxy)-3-bromoimidazo[1,2-a]pyridine;109388-59-2;3-bromo-8-phenylmethoxyimidazo[1,2-a]pyridine;SCHEMBL182618;DTXSID70546561;MNOURXQMSYWOFL-UHFFFAOYSA-N;MFCD21605751;AKOS015991268;BG-0711;8-benzyloxy-3-bromo-imidazo[1,2-a]pyridine;AM20050663;CS-0440739

Chemical Property of 8-(Benzyloxy)-3-bromoimidazo[1,2-a]pyridine

Chemical Property:

• PSA: 26.53000
• LogP: 3.67580
• XLogP3: 4.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 302.00548
• Heavy Atom Count: 18
• Complexity: 271

Purity/Quality:

97% ^*data from raw suppliers

8-(Benzyloxy)-3-bromoimidazo[1,2-a]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=CC=CN3C2=NC=C3Br

Technology Process of 8-(Benzyloxy)-3-bromoimidazo[1,2-a]pyridine

There total 3 articles about 8-(Benzyloxy)-3-bromoimidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

8-(phenylmethoxy)imidazo[1,2-a]pyridine (96428-16-9) → bromo-3 benzyloxy-8 imidazo<1,2-a>pyridine (109388-59-2)

Guidance literature:

With bromine; In ethanol; water; for 8h; Ambient temperature;

Reference yield:

2-amino-3-benzyloxypyridine (24016-03-3) → bromo-3 benzyloxy-8 imidazo<1,2-a>pyridine (109388-59-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / NaHCO₃ / ethanol; H₂O / 8 h / Heating

2: 68 percent / Br₂ / H₂O; ethanol / 8 h / Ambient temperature

With bromine; sodium hydrogencarbonate; In ethanol; water;

Reference yield:

benzyl chloride (100-44-7) → bromo-3 benzyloxy-8 imidazo<1,2-a>pyridine (109388-59-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / 40percent aq. NaOH, Adogen 464 / CH₂Cl₂ / Ambient temperature

2: 70 percent / NaHCO₃ / ethanol; H₂O / 8 h / Heating

3: 68 percent / Br₂ / H₂O; ethanol / 8 h / Ambient temperature

With sodium hydroxide; adogen 464; bromine; sodium hydrogencarbonate; In ethanol; dichloromethane; water;

upstream raw materials:

8-(phenylmethoxy)imidazo[1,2-a]pyridine

2-amino-3-benzyloxypyridine

benzyl chloride

Downstream raw materials:

8-benzyloxy-3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-imidazo[1,2-a]pyridine

N-(4-(methylsulfonyl)phenyl)-3-((trimethylsilyl)ethynyl)imidazo[1,2-a]pyridin-8-amine

8-(benzyloxy)-3-((trimethylsilyl)ethynyl)imidazo[1,2-a]pyridine

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