IMIDAZO[1,2-A]PYRIDINE-2-CARBOHYDRAZIDE

Base Information

• Chemical Name: IMIDAZO[1,2-A]PYRIDINE-2-CARBOHYDRAZIDE
• CAS No.: 119448-27-0
• Molecular Formula: C8H8N4O
• Molecular Weight: 176.178
• Hs Code.: 2933990090
• Mol file: 119448-27-0.mol

Synonyms:imidazo[1,2-a]pyridine-2-carboxylic acid hydrazide;imidazo[1,2-a]pyridin-2-carboxaldehyde;2-Formylimidazo[1,2-a]pyridine;Imidazo[1,2-a]pyridine-2-carboxaldehyde;

Chemical Property of IMIDAZO[1,2-A]PYRIDINE-2-CARBOHYDRAZIDE

Chemical Property:

• PSA: 72.42000
• LogP: 1.02900

Purity/Quality:

97% ^*data from raw suppliers

Imidazo[1,2-a]pyridine-2-carbohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of IMIDAZO[1,2-A]PYRIDINE-2-CARBOHYDRAZIDE

There total 4 articles about IMIDAZO[1,2-A]PYRIDINE-2-CARBOHYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

ethyl 3-imidazo[1,2-a]pyridine-2-carboxylate (38922-77-9) → imidazo[1,2-a]pyridine-2-carboxylic acid hydrazide (119448-27-0)

Guidance literature:

With hydrazine hydrate; In ethanol; for 60h; Heating;

DOI:10.1016/S0040-4020(01)01141-3

Reference yield:

ethyl imidazo[1,2-a]pyridine-2-carboxylate hydrobromide (38922-77-9) → imidazo[1,2-a]pyridine-2-carboxylic acid hydrazide (119448-27-0)

Guidance literature:

With hydrazine; In ethanol; for 2h; Heating;

DOI:10.3906/kim-1307-14

Reference yield:

2-aminopyridine (504-29-0) → imidazo[1,2-a]pyridine-2-carboxylic acid hydrazide (119448-27-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1,2-dimethoxyethane / 2 h / 20 °C

2: ethanol; water / 2 h / Reflux

3: hydrazine / ethanol / 2 h / Heating

With hydrazine; In 1,2-dimethoxyethane; ethanol; water;

DOI:10.3906/kim-1307-14

upstream raw materials:

ethyl 3-imidazo[1,2-a]pyridine-2-carboxylate

2-amino-1-(3-ethoxy-2,3-dioxopropyl)pyridinium bromide

2-aminopyridine

ethyl imidazo[1,2-a]pyridine-2-carboxylate hydrobromide

Downstream raw materials:

N-benzyl-2-(imidazo[1,2-a]pyridin-2-ylcarbonyl)hydrazinecarbothioamide