Carbonic acid, (3S,4R)-1,3-diMethyl-4-[3-(1-Methylethoxy)phenyl]-4-piperidinyl ethyl ester (9CI)

Base Information

Chemical Name:Carbonic acid, (3S,4R)-1,3-diMethyl-4-[3-(1-Methylethoxy)phenyl]-4-piperidinyl ethyl ester (9CI)
CAS No.:143957-08-8
Molecular Formula:C19H29NO4
Molecular Weight:335.43800
Hs Code.:
Mol file:143957-08-8.mol

Synonyms:AJ 76;2-Naphthalenamine,1,2,3,4-tetrahydro-5-methoxy-1-methyl-N-propyl-,(1S-cis);carbonic acid,ethyl (3S,4R)-1,3-dimethyl-4-<3-(1-methylethoxy)phenyl>-4-piperidinyl ester;cis-(+-)carbonic acid ethyl 1,3-dimethyl-4-[3-(l-methylethoxy)phenyl]-4-piperidinyl ester;cis-(+)-5-methoxy-1-methyl-2-(n-propylamino)tetralin hydrochloride;ethyl (3S,4R)-1,3-dimethyl-4-[3-(1-methylethoxy)phenyl]-4-piperidinyl ester;(1S,2R)-cis-5-methoxy-1-methyl-2-(n-propylamino)tetralin;(+)-AJ 76 hydrochloride;5-methoxy-1-methyl-2-(n-propylamino)tetralin;cis-(+)-5-methoxy-1-methyl-2-(n-propylamino)tetralin;cis-(+)-(1S,2R)-5-methoxy-1-methyl-2-(n-propylamino)tetralin;ethyl (3S,4R)-1,3-dimethyl-4-[3-(1-methylethoxy)phenyl]-4-piperidinyl ester carbonic acid;

Suppliers and Price of Carbonic acid, (3S,4R)-1,3-diMethyl-4-[3-(1-Methylethoxy)phenyl]-4-piperidinyl ethyl ester (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 6 raw suppliers

Chemical Property of Carbonic acid, (3S,4R)-1,3-diMethyl-4-[3-(1-Methylethoxy)phenyl]-4-piperidinyl ethyl ester (9CI)

Chemical Property:

PSA：48.00000
LogP:3.75170

Purity/Quality:: NLT 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Carbonic acid, (3S,4R)-1,3-diMethyl-4-[3-(1-Methylethoxy)phenyl]-4-piperidinyl ethyl ester (9CI)

There total 6 articles about Carbonic acid, (3S,4R)-1,3-diMethyl-4-[3-(1-Methylethoxy)phenyl]-4-piperidinyl ethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 172376-39-5
cis-(+/-)-1,3-dimethyl-4-[3-(1-methyl-ethoxy)phenyl]-4-piperidinol

: 541-41-3
chloroformic acid ethyl ester

: 143957-08-8,149541-62-8
carbonic acid, ethyl (3S,4R)-1,3-dimethyl-4-<3-(1-methylethoxy)phenyl>-4-piperidinyl ester

Guidance literature:: cis-(+/-)-1,3-dimethyl-4-[3-(1-methyl-ethoxy)phenyl]-4-piperidinol; chloroformic acid ethyl ester; With triethylamine; In ethyl acetate; at 0 - 25 ℃; for 3.5h;

With sodium hydroxide; In ethanol; water; ethyl acetate; at 0 - 38 ℃; for 0.333333h; pH=> 10;

Reference yield:

: 541-41-3
chloroformic acid ethyl ester

: 145340-44-9,172376-39-5
1,3-dimethyl-4-[3-(propan-2-yloxy)phenyl]-4-piperidinol

: 143957-08-8,149541-62-8
carbonic acid, ethyl (3S,4R)-1,3-dimethyl-4-<3-(1-methylethoxy)phenyl>-4-piperidinyl ester

Guidance literature:: With sodium hydroxide; In ethyl acetate;

Reference yield:

: 4629-80-5
1,3-dimethyl-4-piperidinone

: 143957-08-8,149541-62-8
carbonic acid, ethyl (3S,4R)-1,3-dimethyl-4-<3-(1-methylethoxy)phenyl>-4-piperidinyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) THF, heptane, -75 deg C, 1 h, 2.) -60 deg C, 1.5 h

2: ethyl acetate / 3 h / 25 °C

With n-butyllithium; In ethyl acetate;
DOI:10.1021/jo951403y