2-Phthalimidopropionic acid

Base Information

• Chemical Name: 2-Phthalimidopropionic acid
• CAS No.: 21860-84-4
• Molecular Formula: C11H9NO4
• Molecular Weight: 219.197
• Mol file: 21860-84-4.mol

Synonyms:

Chemical Property of 2-Phthalimidopropionic acid

Chemical Property:

• Melting Point: 162-164°C

Purity/Quality:

97% ^*data from raw suppliers

PHTHALOYL-DL-ALANINE AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s): 86452
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Phthalimidopropionic acid

There total 7 articles about 2-Phthalimidopropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

diphenyl (1,3-dioxoisoindolin-2-yl)phosphonate (80824-98-2) + rac-Ala-OH (302-72-7,25191-17-7,18875-37-1) → diphenylphosphoroamidate (2015-56-7) + 2-phthalimidopropionic acid (21860-84-4)

Guidance literature:

With 1,5-Diazabicyclo[5.4.0]undec-5-ene; In ethanol; at 78 ℃; for 1h; Heating;

Reference yield: 26.0%

phthalic anhydride (85-44-9) + rac-Ala-OH (302-72-7,25191-17-7,18875-37-1) → 2-phthalimidopropionic acid (21860-84-4)

Guidance literature:

With acetic acid; for 2h; Inert atmosphere; Schlenk technique; Reflux;

DOI:10.1021/acs.orglett.9b03338

Reference yield:

phthaloylasparic anhydride (4443-40-7) → 3-phthalimidopropanoic acid (3339-73-9) + 2-phthalimidopropionic acid (21860-84-4)

Guidance literature:

With hydrogenchloride; bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; tricyclohexylphosphine; Yield given. Multistep reaction. Yields of byproduct given; 1.) benzene, 23 deg C, 25h.;

DOI:10.1016/S0040-4039(00)97733-5

upstream raw materials:

phthalic anhydride

rac-Ala-OH

phthaloylasparic anhydride

diphenyl (1,3-dioxoisoindolin-2-yl)phosphonate

Downstream raw materials:

N,N-phthaloyl-DL-alanin-anilide

N,N-phthaloyl-alanine-phenyl ester

2-[2-(3,5-Dioxo-2-phenyl-pyrazolidin-1-yl)-1-methyl-2-oxo-ethyl]-isoindole-1,3-dione

N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionamide