3339-73-9Relevant articles and documents
Crystal structure, thermal, luminescent and terahertz time domain spectroscopy of magnesium N-phthaloyl-β-alaninate: A combined experimental and theoretical study
Nadeem, Muhammad,Bhatti, Moazzam H.,Sayin, Koray,Yunus, Uzma,Mehmood, Mazhar,Mehboob, Shoaib,Fl?rke, Ulrich
, p. 1 - 8 (2018)
A magnesium complex using N-phthaloyl-β-alanine (NPA) as ligand was synthesized and its crystal structure was characterized by single-crystal X-ray diffraction analysis. The Fourier transformation infrared spectroscopy (FTIR), thermogravimetry (TG) and differential thermal analysis (DTA), fluorescence spectroscopy and terahertz time-domain spectroscopy (THz-TDS) were performed for magnesium N-phthaloyl-β-alaninate (MgNPA). The coordination geometry around Mg (II) has found to be distorted octahedral and the coordination mode of NPA in MgNPA is monodentate i.e. η1μ1. The significant enhancement was observed in the emission intensity of MgNPA complex as compared to the ligand NPA during solid state photoluminescence spectroscopy. The computational investigations of the complex were carried out at B3LYP/6-31 + G (d,p) level in gas phase to support our experimental results. The small energy gap between frontier molecular orbitals (FMOs) manifested that MgNPA is a very reactive, chemically soft and optically active complex. The terahertz time domain spectroscopy of the complex and ligand was performed in order to characterize as well as to find out refractive index and absorption coefficient in 0.2–3.2 THz frequency range. Both the complex and ligand shows the characteristic absorption peaks in this frequency range. The decrease in refractive index is observed by the complexation of NPA with Mg.
Thiamin Biosynthesis in Yeast. Origin of the Five-Carbon Unit of the Thiazole Moiety
White, Robert L.,Spenser, Ian D.
, p. 4934 - 4943 (1982)
Radioactivity from D--, D--, and D-glucose, from D-fructose, and from glycerol is incorporated nonrandomly into the C5 chain of the thiazole moiety of thiamin in Saccharomyces cerevisiae.The incorporation pattern leads to inference that the C5 chain is derived from a 2-pentulose, which is generated from the hexose precursors by the oxidative as well as by the nonoxidative pentose phosphate pathway.A chemically rational scheme for the biogenesis of the thiazole moiety of thiamin is presented.
Oxidative damage of proline residues by nitrate radicals (NO3): A kinetic and product study
Nathanael, Joses G.,Nuske, Madison R.,Richter, Annika,White, Jonathan M.,Wille, Uta
, p. 6949 - 6957 (2020/10/02)
Tertiary amides, such as in N-acylated proline or N-methyl glycine residues, react rapidly with nitrate radicals (NO3) with absolute rate coefficients in the range of 4-7 × 108 M-1 s-1 in acetonitrile. The major pathway proceeds through oxidative electron transfer (ET) at nitrogen, whereas hydrogen abstraction is only a minor contributor under these conditions. However, steric hindrance at the amide, for example by alkyl side chains at the α-carbon, lowers the rate coefficient by up to 75%, indicating that NO3-induced oxidation of amide bonds proceeds through initial formation of a charge transfer complex. Furthermore, the rate of oxidative damage of proline and N-methyl glycine is significantly influenced by its position in a peptide. Thus, neighbouring peptide bonds, particularly in the N-direction, reduce the electron density at the tertiary amide, which slows down the rate of ET by up to one order of magnitude. The results from these model studies suggest that the susceptibility of proline residues in peptides to radical-induced oxidative damage should be considerably reduced, compared with the single amino acid.
Substituted 1,3-dioxoisoindoline-4-aminoquinolines coupled via amide linkers: Synthesis, antiplasmodial and cytotoxic evaluation
Rani, Anu,Legac, Jenny,Rosenthal, Philip J.,Kumar, Vipan
, (2019/04/17)
Synthesis of C-5-substituted 1,3-dioxoisoindoline-4-aminoquinolines having amide group as a spacer was developed with an intent to evaluate their antiplasmodial activities. The synthesized dioxoisoindoline-aminoquinolines tethered with β-alanine as a spacer and secondary amine as substituent displayed good anti-plasmodial activities. Compound 7j, with an optimum combination of β-alanine and an ethyl chain length as linker along with diethylamine as the secondary amine counterpart at dioxoisoindoline proved to be most potent and non-cytotoxic with IC50 of 0.097 μM against W2 strain of P. falciparum and a selective index of >2000.
