1-Methyl-1H-pyrrolo[2,3-b]pyridine-2,3-dione

Base Information

• Chemical Name: 1-Methyl-1H-pyrrolo[2,3-b]pyridine-2,3-dione
• CAS No.: 281192-94-7
• Molecular Formula: C8H6N2O2
• Molecular Weight: 162.15
• DSSTox Substance ID: DTXSID701259360
• Nikkaji Number: J1.284.258I
• Mol file: 281192-94-7.mol

Synonyms:1-Methyl-1H-pyrrolo[2,3-b]pyridine-2,3-dione;281192-94-7;SCHEMBL2477071;DTXSID701259360;1-Methyl-7-azaindoline-2,3-dione;1-METHYLPYRROLO[2,3-B]PYRIDINE-2,3-DIONE;1-methyl-1H,2H,3H-pyrrolo[2,3-b]pyridine-2,3-dione

Chemical Property of 1-Methyl-1H-pyrrolo[2,3-b]pyridine-2,3-dione

Chemical Property:

• XLogP3: 0.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 162.042927438
• Heavy Atom Count: 12
• Complexity: 239

Purity/Quality:

98% ^*data from raw suppliers

1-Methyl-1H-pyrrolo[2,3-b]pyridine-2,3-dione 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN1C2=C(C=CC=N2)C(=O)C1=O

Technology Process of 1-Methyl-1H-pyrrolo[2,3-b]pyridine-2,3-dione

There total 5 articles about 1-Methyl-1H-pyrrolo[2,3-b]pyridine-2,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-methyl-1H-pyrrolo[2,3-b]pyridine (27257-15-4) → N-Methyl-7-azaisatin (281192-94-7)

Guidance literature:

With water; iodine; chloramine-B; potassium carbonate; In acetonitrile; at 20 ℃; for 12h;

DOI:10.1002/ejoc.201600061

Reference yield: 90.0%

3-bromo-1-methyl-1H-pyrrolo[2,3-b]pyridine (281192-91-4) → N-Methyl-7-azaisatin (281192-94-7) + 2,3-dibromo-1-methyl-1H-pyrrolo[2,3-b]pyridine + 3,3-dibromo-1-methyl-7-azaoxindole

Guidance literature:

With N-Bromosuccinimide; dimethyl sulfoxide; at 60 - 80 ℃; for 26h;

DOI:10.3987/COM-99-8792

Reference yield: 50.0%

1-methyl-1H-pyrrolo[2,3-b]pyridine (27257-15-4) → (3E)-7,7'-diaza-1,1'-dimethylisoindigo (1202876-68-3) + (3E)-5-bromo-7,7'-diaza-1,1'-dimethylisoindigo (1202876-69-4) + N-Methyl-7-azaisatin (281192-94-7) + 2,3-dibromo-1-methyl-1H-pyrrolo[2,3-b]pyridine

Guidance literature:

With N-Bromosuccinimide; dimethyl sulfoxide;

DOI:10.1021/np9003905

upstream raw materials:

3-bromo-1-methyl-1H-pyrrolo[2,3-b]pyridine

1-methyl-1H-pyrrolo[2,3-b]pyridine

7-Azaindole

1H-pyrrolo[2,3-b]pyridine-2,3-dione