7-(Benzyloxy)-4-bromo-1H-indole

Base Information

Chemical Name:7-(Benzyloxy)-4-bromo-1H-indole
CAS No.:476622-92-1
Molecular Formula:C15H12BrNO
Molecular Weight:302.16600
Hs Code.:
DSSTox Substance ID:DTXSID501295354
Mol file:476622-92-1.mol

Synonyms:7-(Benzyloxy)-4-bromo-1H-indole;476622-92-1;4-Bromo-7-benzyloxy-1H-indole;4-bromo-7-phenylmethoxy-1H-indole;SCHEMBL3621324;HWDMSYHNPIYTJF-UHFFFAOYSA-N;DTXSID501295354;4-Bromo-7-(phenylmethoxy)-1H-indole;PS-15496;F77950;EN300-12577993

Suppliers and Price of 7-(Benzyloxy)-4-bromo-1H-indole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4-BROMO-7-BENZYLOXY-1H-INDOLE 95.00%
5MG
$ 498.72

Total 7 raw suppliers

Chemical Property of 7-(Benzyloxy)-4-bromo-1H-indole

Chemical Property:

PSA：25.02000
LogP:4.50940
XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:3
Exact Mass:301.01023
Heavy Atom Count:18
Complexity:267

Purity/Quality:

97% ^*data from raw suppliers

4-BROMO-7-BENZYLOXY-1H-INDOLE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)COC2=C3C(=C(C=C2)Br)C=CN3

Technology Process of 7-(Benzyloxy)-4-bromo-1H-indole

There total 2 articles about 7-(Benzyloxy)-4-bromo-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 383868-64-2
1-(benzyloxy)-4-bromo-2-nitrobenzene

: 1826-67-1
vinyl magnesium bromide

: 476622-92-1
7-benzyloxy-4-bromoindole

Guidance literature:: In tetrahydrofuran; at -40 ℃; for 4h;
DOI:10.1021/ja027822b

Reference yield:

: 1001395-44-3
1-{(E)-2-[3-(benzyloxy)-6-bromo-2-nitrophenyl]vinyl}pyrrolidine

: 476622-92-1
7-benzyloxy-4-bromoindole

Guidance literature:: With iron; acetic acid; for 2h;

Reference yield:

: 476622-92-1
7-benzyloxy-4-bromoindole

: 476623-24-2
2-[7-benzyloxy-3-{5-[6-bromo-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-6-methoxy-pyrazin-2-yl}-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indol-4-yl]-propionaldehyde

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 23 °C

1.2: 13 / 6 h / 23 °C

2.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.25 h / -78 °C

2.2: 13; 17 / 1.5 h / -78 °C

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; benzene / 2 h / 80 °C

4.1: hydrogen / palladium / benzene / 1 h / 760.05 Torr

5.1: N-Bromosuccinimide / tetrahydrofuran / 0.08 h

6.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.25 h / -78 °C

6.2: 13; 17 / 1 h / -78 °C

7.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; benzene / 72 h / 50 °C

8.1: pyridine hydrogenfluoride / tetrahydrofuran / 1.5 h / 0 °C

9.1: Dess-Martin periodane / dichloromethane / 0.33 h / 23 °C

With N-Bromosuccinimide; hydrogen; tert.-butyl lithium; sodium hydride; sodium carbonate; Dess-Martin periodane; pyridine hydrogenfluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium; In tetrahydrofuran; methanol; dichloromethane; pentane; benzene; 3.1: Suzuki coupling / 7.1: Suzuki coupling;
DOI:10.1021/ja027822b