4-[5-(Trifluoromethyl)pyridin-2-yl]benzyl chloride

Base Information

• Chemical Name: 4-[5-(Trifluoromethyl)pyridin-2-yl]benzyl chloride
• CAS No.: 613239-76-2
• Molecular Formula: C13H9ClF3N
• Molecular Weight: 271.66500
• Hs Code.: 2933399990
• Mol file: 613239-76-2.mol

Synonyms:

Chemical Property of 4-[5-(Trifluoromethyl)pyridin-2-yl]benzyl chloride

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 77-78oC
• Boiling Point: 327.876oC at 760 mmHg
• PKA: 2.02±0.25(Predicted)
• Flash Point: 152.094oC
• PSA: 12.89000
• Density: 1.299g/cm3
• LogP: 4.50620

Purity/Quality:

98%Min ^*data from raw suppliers

4-[5-(Trifluoromethyl)pyridin-2-yl]benzylchloride 95% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-[5-(Trifluoromethyl)pyridin-2-yl]benzyl chloride

There total 1 articles about 4-[5-(Trifluoromethyl)pyridin-2-yl]benzyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[4-(5-trifluoromethyl-pyridin-2-yl)-phenyl]-methanol (613239-75-1) → 2-(4-chloromethylphenyl)-5-trifluoromethylpyridine (613239-76-2)

Guidance literature:

Reference yield:

2-(4-chloromethylphenyl)-5-trifluoromethylpyridine (613239-76-2) → 2-{3-Methoxy-4-[4-(5-trifluoromethyl-pyridin-2-yl)-benzylsulfanyl]-phenyl}-2-methyl-propionic acid methyl ester (779200-30-5)

Guidance literature:

With caesium carbonate; In water; acetonitrile;

Reference yield:

2-(4-chloromethylphenyl)-5-trifluoromethylpyridine (613239-76-2) + (4-mercapto-2-methyl-phenoxy)-acetic acid methyl ester (56077-47-5) → {2-Methyl-4-[4-(5-trifluoromethyl-pyridin-2-yl)-benzylsulfanyl]-phenoxy}-acetic Acid Methyl Ester (613239-95-5)

Guidance literature:

upstream raw materials:

[4-(5-trifluoromethyl-pyridin-2-yl)-phenyl]-methanol

Downstream raw materials:

{2-Methyl-4-[4-(5-trifluoromethyl-pyridin-2-yl)-benzylsulfanyl]-phenoxy}-acetic Acid Methyl Ester

{5-Methoxy-2-methyl-4-[4-(5-trifluoromethyl-pyridin-2-yl)-benzylsulfanyl]-phenoxy}-acetic Acid Methyl Ester

{5-Methyl-7-[4-(5-trifluoromethyl-pyridin-2-yl)-benzylsulfanyl]-indan-4-yloxy}-acetic Acid Methyl Ester

[8-(4'-Trifluoromethyl-biphenyl-4-ylmethylsulfanyl)-chroman-5-yloxy]-acetic Acid Methyl Ester

Refernces

• 1、 -. "Compounds that modulate PPAR activity and methods for their preparation". Page 33. . Retrieved 2010/02/05.