56077-47-5

Upstream product

• 67-56-1 methanol 
• 91427-62-2 (4-chlorosulfonyl-2-methyl-phenoxy)-acetic acid ethyl ester 
• 93917-68-1 ethyl (2-methylphenoxy)acetate 
• 583883-84-5 (4-dimethylthiocarbamoyloxy-2-methyl-phenoxy)-acetic acid methyl ester 
• 317319-09-8 (4-acetoxy-2-methylphenoxy)acetic acid methyl ester 
• 166953-80-6 (4-acetyl-2-methylphenoxy)acetic acid methyl ester 
• 317319-10-1 methyl (4-hydroxy-2-methylphenoxy)acetate 
• 876-02-8 4-hydroxy-3-methylphenyl methyl ketone 
• 95-48-7 ortho-cresol 
• 2989-17-5 methyl 2-methylphenoxy acetate 
• 56077-64-6 (2-Methyl-4-thiocyanato-phenoxy)-acetic acid methyl ester 
• 583883-85-6 (4-dimethylcarbamoylsulfanyl-2-methyl-phenoxy)-acetic acid methyl ester 

Downstream Products

• 873066-40-1 {4-[4-furan-2-yl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethylsulfanyl]-2-methyl-phenoxy}-acetic acid methyl ester 
• 873066-41-2 {2-methyl-4-[4-phenyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethylsulfanyl]-phenoxy}-acetic acid methyl ester 
• 919285-71-5 {4-[3-(2,6-dichloro-phenyl)-isoxazol-5-ylmethylsulfanyl]-2-methyl-phenoxy}-acetic acid methyl ester 
• 613239-70-6 {2-Methyl-4-[4-(4-trifluoromethyl-benzyloxy)-benzylsulfanyl]-phenoxy}-acetic Acid Methyl Ester 
• 673479-09-9 {4-[3,3-Bis-(4-bromo-phenyl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid 
• 613239-53-5 [4-(Biphenyl-4-ylmethylsulfanyl)-2-methyl-phenoxy]-acetic Acid Methyl Ester 
• 613239-66-0 [4-(4-benzyloxy-benzylsulfanyl)-2-methyl-phenoxy]-acetic acid mehyl ester 
• 719293-47-7 [4-(3-{4'-[3-(4-methoxycarbonylmethoxy-3-methyl-phenylsulfanyl)-propyl]-2,2'-bis-trifluoromethyl-biphenyl-4-yl}-propylsulfanyl)-2-methyl-phenoxy]-acetic acid methyl ester 
• 918164-59-7 methyl (2-methyl-4-[4-methyl-5-(4-trifluoromethylphenyl)thien-2-ylmethylthio]phenoxy)acetate 
• 918164-60-0 methyl (2-methyl-4-[3-methyl-5-(4-trifluoromethylphenyl)thien-2-ylmethylthio]phenoxy)acetate 
• 613240-25-8 {2-Methyl-4-[3-(4-trifluoromethyl-phenyl)-isoxazol-5-ylmethylsulfanyl]-phenoxy}-acetic Acid Methyl Ester 
• 613240-05-4 [4-(4-Acetoxy-benzylsulfanyl)-2-methyl-phenoxy]-acetic Acid Methyl Ester 

Relevant academic research and scientific papers

Base Catalysis Enables Access to α,α-Difluoroalkylthioethers

A nucleophilic addition reaction of aryl thiols to readily available β,β-difluorostyrenes provides α,α-difluoroalkylthioethers. The reaction proceeds through an unstable anionic intermediate, prone to eliminate fluoride and generate α-fluorovinylthioethers. However, the use of base catalysis overcomes the facile β-fluoride elimination, generating α,α-difluoroalkylthioethers in excellent yields and selectivities.

Discovery of highly potent and selective benzyloxybenzyl-based peroxisome proliferator-activator receptor (PPAR) δ agonists

A series of 1,4-benzyloxybenzylsulfanylaryl carboxylic acids were prepared and their activities for PPAR receptor subtypes (α, δ, and γ) with potential indications for the treatment of dyslipidemia were investigated. Analog 13a displayed the greatest binding affinity (IC50 = 10 nM) and selectivity (120-fold) for PPARδ over PPARα. Many of the analogs investigated were found to be highly selective for PPARδ and were dependent on the point of attachment of the substituent. In the 1,4-series, analog 28e was found to be the most potent (IC50 = 1.7 nM) and selective (>1000-fold) compound for PPARδ. None of the compounds tested showed appreciable binding affinity for PPARγ.

DICARBOXYLIC ACID DERIVATIVES AS PPAR-AGONISTS

A novel class of dicarboxylic acid derivatives, the use of these compounds as phar-maceutical compositions, pharmaceutical compositions comprising the compounds and meth-ods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Prolifera-tor-Activated Receptors (PPAR).

Compounds that modulate PPAR activity and methods of preparation

This invention relates to compounds that alter PPAR activity. The invention also relates to pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing dyslipidemia, hypercholesterolemia, obesity, hyperglycemia, atherosclerosis, hypertriglyceridemia and hyperinsulinemia in a mammal. The present invention also relates to methods for making the disclosed compounds.

Novel compounds, their preparation and use

A novel class of dicarboxylic acid derivatives, the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Proliferator-Activated Receptors (PPAR).

Compounds that modulate PPAR activity and methods for their preparation

This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing disipidemia, hypercholesteremia, obesity, eating disorders, hyperglycemia, atherosclerosis, hypertriglyceridemia, hyperinsulinemia and diabetes in a mammal as well as methods of supressing appetite and modulating leptin levels in a mammal. The present invention also discloses methods for making the disclosed compounds.

Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ) - Synthesis and biological activity

We report the synthesis and biological activity of a new series of small molecule agonists of the human Peroxisome Proliferator-Activated Receptor δ (PPARδ). Several hits were identified from our original libraries containing lipophilic carboxylic acids. Optimization of these hits by structure-guided design led to 7k (GW501516) and 7l (GW0742), which shows an EC50 of 1.1 nM against PPARδ with 1000-fold selectivity over the other human subtypes.

Novel compounds, their preparation and use

A novel class of dicarboxylic acid derivatives, the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Proliferator-Activated Receptors (PPAR).