(+/-)-1-METHOXY-1-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE

Base Information

• Chemical Name: (+/-)-1-METHOXY-1-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE
• CAS No.: 64312-89-6
• Molecular Formula: C10H8ClF3O2
• Molecular Weight: 252.621
• Mol file: 64312-89-6.mol

Synonyms:Mosher's acid chloride;Mosher reagent;

Chemical Property of (+/-)-1-METHOXY-1-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE

Chemical Property:

• Refractive Index: n20/D 1.471(lit.)
• Boiling Point: 213-214oC(lit.)
• Flash Point: 190 °F
• PSA: 26.30000
• Density: 1.327
• LogP: 3.30380
• Storage Temp.: Keep Cold
• Sensitive.: Moisture Sensitive

Purity/Quality:

98%,99%, ^*data from raw suppliers

α-Methoxy-α-trifluoromethylphenylacetyl chloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34-43
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (+/-)-1-METHOXY-1-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE

There total 4 articles about (+/-)-1-METHOXY-1-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

MTPA (20445-31-2,56135-03-6,81655-41-6,17257-71-5) → Mosher's acid chloride (64312-89-6)

Guidance literature:

With oxalyl dichloride;

DOI:10.1016/S0040-4039(00)99570-4

Reference yield:

2,2,2-Trifluoroacetophenone (434-45-7) → Mosher's acid chloride (64312-89-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent

2: 61 percent / hydrolysis

3: 20 g / SOCl₂

With thionyl chloride;

Reference yield:

phenylmagnesium bromide → Mosher's acid chloride (64312-89-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 64 percent

2: 90 percent

3: 61 percent / hydrolysis

4: 20 g / SOCl₂

With thionyl chloride;

upstream raw materials:

MTPA

2,2,2-Trifluoroacetophenone

α-methoxy-α-trifluoromethyl-phenyl-acetonitrile

Downstream raw materials:

(S)-2-[(S)-2-(3,3,3-Trifluoro-2-methoxy-2-phenyl-propionylamino)-propionylamino]-propionic acid tert-butyl ester

3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-2-benzyloxy-2-methyl-pent-4-enyl ester

N-((R)-1,2-Dimethyl-propyl)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionamide

3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1R,2S)-1-((R)-6-oxo-tetrahydro-pyran-2-yl)-2-(3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-3-(2,4,6-triisopropyl-benzenesulfonyloxy)-propyl ester

Refernces

• 1、 Webb, Eric W.,Park, John B.,Cole, Erin L.,Donnelly, David J.,Bonacorsi, Samuel J.,Ewing, William R.,Doyle, Abigail G.. "Nucleophilic (Radio)Fluorination of Redox-Active Esters via Radical-Polar Crossover Enabled by Photoredox Catalysis". supporting information. p. 9493 - 9500. Retrieved 2020/05/18.
• 2、 Volchkov, Ivan,Park, Sangho,Lee, Daesung. "Ring strain-promoted allylic transposition of cyclic silyl ethers". supporting information; experimental part. p. 3530 - 3533. Retrieved 2011/09/15.