(2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acid

Base Information

Chemical Name:(2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acid
CAS No.:20445-31-2
Molecular Formula:C10H9F3O3
Molecular Weight:234.175
Hs Code.:29189900
European Community (EC) Number:243-829-5
UNII:27O5L9T1WM
DSSTox Substance ID:DTXSID10897009
Nikkaji Number:J66.197J
Wikidata:Q27254219
Mol file:20445-31-2.mol

Synonyms:20445-31-2;(2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acid;(+)-Mtpa;(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid;(R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acid;(+)-Mosher's Acid;(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid;(R)-MTPA;UNII-27O5L9T1WM;(r)-(+)-a-methoxy-a-trifluoromethylphenylacetic acid;27O5L9T1WM;EINECS 243-829-5;C10H9F3O3;(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid;alpha-Methoxy-alpha-trifluoromethylphenylacetic acid, (+)-;C10-H9-F3-O3;Moshers's acid;(R)-MOSHER ACID;(R)-(+)-Mosher's acid;SCHEMBL236358;(R)-(+)-MTPA ACID;(R)-(+)-MOSHER ACID;DTXSID10897009;(R)-(+)-alpha-Methoxy-alpha-trifluoromethyl-phenylacetic acid;(R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic Acid;AMY32681;MFCD00004184;AKOS005254473;SB35195;BP-12316;M0831;MOSHER'S REAGENT (R)-(+)-FORM [MI];T72051;A814569;(+)-A-Methoxy-A-(trifluoromethyl)phenylacetic acid;J-013327;(R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoicacid;Q27254219;(+)-alpha-methoxy-alpha-trifluoromethylphenylacetic acid;Benzeneacetic acid, a-methoxy-a-(trifluoromethyl)-, (aR)-;(2R)-(+)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoic acid;(R)-(+)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acid;r-(+)-alpha-methoxy-alpha-(trifluoromethyl)phenyl acetic acid;r-(+)-alpha-methoxy-alpha-(trifluoromethyl)phenylacetic acid;(R)-(+)-3,3,3-TRIFLUORO-2-PHENYL-2-METHOXYPROPANOIC ACID;(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid, 99%;(R)-(+)-.ALPHA.-METHOXY-.ALPHA.-(TRIFLUOROMETHYL)PHENYLACETIC ACID;.ALPHA.-METHOXY-.ALPHA.-TRIFLUOROMETHYLPHENYLACETIC ACID, (+)-;(R)-(+)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETIC ACID [OPTICAL RESOLVING];BENZENEACETIC ACID, .ALPHA.-METHOXY-.ALPHA.-(TRIFLUOROMETHYL)-, (.ALPHA.R)-;(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid, for chiral derivatization, >=99.0%

Suppliers and Price of (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
α-Methoxy-α-(trifluoromethyl)phenylacetic acid
500mg
$ 90.00

TCI Chemical
(R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic Acid [Optical Resolving] >98.0%(GC)(T)
5g
$ 309.00

TCI Chemical
(R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic Acid [Optical Resolving] >98.0%(GC)(T)
1g
$ 89.00

SynQuest Laboratories
(R)-3,3,3-Trifluoro-2-methoxy-2-phenylpropanoic acid 99%
1 g
$ 74.00

SynQuest Laboratories
(R)-3,3,3-Trifluoro-2-methoxy-2-phenylpropanoic acid 99%
5 g
$ 296.00

Sigma-Aldrich
(R)-(+)-α-Methoxy-α-trifluoromethylphenylacetic acid for chiral derivatization, ≥99.0%
1g
$ 438.00

Sigma-Aldrich
(R)-(+)-α-Methoxy-α-trifluoromethylphenylacetic acid 99%
5g
$ 389.00

Sigma-Aldrich
(R)-(+)-α-Methoxy-α-trifluoromethylphenylacetic acid for chiral derivatization, ≥99.0%
250mg
$ 141.00

Sigma-Aldrich
(R)-(+)-α-Methoxy-α-trifluoromethylphenylacetic acid 99%
1g
$ 129.00

Sigma-Aldrich
(R)-(+)-α-Methoxy-α-trifluoromethylphenylacetic acid 99%
250mg
$ 57.80

Total 39 raw suppliers

Chemical Property of (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acid

Chemical Property:

Vapor Pressure:0.164mmHg at 25°C
Melting Point:46-49 °C(lit.)
Refractive Index:n20/D 1.473(lit.)
Boiling Point:287.226 °C at 760 mmHg
PKA:1.47±0.10(Predicted)
Flash Point:134.154 °C
PSA：46.53000
Density:1.35 g/cm³
LogP:2.17520
Storage Temp.:2-8°C
Sensitive.:Hygroscopic
Solubility.:Soluble in methanol (50 mg/ 1 ml).
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:234.05037863
Heavy Atom Count:16
Complexity:259

Purity/Quality:

97% ^*data from raw suppliers

α-Methoxy-α-(trifluoromethyl)phenylacetic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(C1=CC=CC=C1)(C(=O)O)C(F)(F)F
Isomeric SMILES:CO[C@](C1=CC=CC=C1)(C(=O)O)C(F)(F)F
Uses (R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid is widely used reagent for determination of optical purities of alcohols and amines by 1H or 19F NMR. Mosher′s acid chloride is used as a dervatization agent for β-arylethylamines, enantiomeric alcohols, and enantiomeric amines. It is also a reagent used for the determination of enantiomeric purity and absolute configuration of alcohols and amines by NMR.

Technology Process of (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acid

There total 64 articles about (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: C₂₆H₃₁F₃O₃

: 20445-31-2
R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid

: 65253-04-5
(-)-8-phenylmenthol

Guidance literature:: With potassium hydroxide; In methanol; at 70 ℃; Schlenk technique; Inert atmosphere;
DOI:10.1021/jacs.5b01517

Reference yield: 82.0%

: 537695-87-7
(R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanol

: 20445-31-2
R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid

Guidance literature:: With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite; In phosphate buffer; acetonitrile; at 55 ℃; for 4h;
DOI:10.1016/S0957-4166(03)00023-5