1H-Indole-6-sulfonic acid, 2,3-dihydro-

Base Information

• Chemical Name: 1H-Indole-6-sulfonic acid, 2,3-dihydro-
• CAS No.: 80279-71-6
• Molecular Formula: C8H9NO3S
• Molecular Weight: 199.22700
• Mol file: 80279-71-6.mol

Synonyms:2,3-dihydro-1H-indole-6-sulfonic acid;indoline-6-sulfonic acid;

Chemical Property of 1H-Indole-6-sulfonic acid, 2,3-dihydro-

Chemical Property:

• PSA: 74.78000
• LogP: 2.12010

Purity/Quality:

98% ^*data from raw suppliers

2,3-dihydro-1H-indole-6-sulfonicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Indole-6-sulfonic acid, 2,3-dihydro-

There total 2 articles about 1H-Indole-6-sulfonic acid, 2,3-dihydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-indoline (496-15-1) → Indoline-6-sulfonic acid (80279-71-6)

Guidance literature:

With fuming sulfuric acid; at 135 ℃; for 0.5h;

Reference yield:

→ Indoline-6-sulfonic acid (80279-71-6)

Guidance literature:

Reference yield:

Indoline-6-sulfonic acid (80279-71-6) → 1-{6-[(4-chlorophenyl)amino]-4-pyrimidinyl}-N-methyl-2,3-dihydro-1H-indole-6-sulfonamide hydrochloride

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine / acetic acid / 24 h / 100 °C

2: trichlorophosphate / N,N-dimethyl-formamide / acetonitrile / 1 h / Reflux

3: dichloromethane; water / 22 °C

4: hydrogenchloride / 2 h / 20 °C

5: hydrogenchloride / isopropyl alcohol / 0.5 h / 150 °C / Microwave irradiation

With pyridine; hydrogenchloride; trichlorophosphate; N,N-dimethyl-formamide; In dichloromethane; water; acetic acid; isopropyl alcohol; acetonitrile;

upstream raw materials:

1-indoline

Downstream raw materials:

1-acetyl-2,3-dihydro-1H-indole-6-sulfonylchloride

2-[3,6-Bis-(6-dimethylsulfamoyl-2,3-dihydro-indol-1-yl)-9H-xanthen-9-yl]-benzenesulfonic acid

2-[3,6-Bis-(6-dimethylsulfamoyl-2,3-dihydro-indol-1-yl)-9H-xanthen-9-yl]-benzenesulfonyl chloride