Technology Process of 2-[3,6-Bis-(6-dimethylsulfamoyl-2,3-dihydro-indol-1-yl)-9H-xanthen-9-yl]-benzenesulfonyl chloride
There total 8 articles about 2-[3,6-Bis-(6-dimethylsulfamoyl-2,3-dihydro-indol-1-yl)-9H-xanthen-9-yl]-benzenesulfonyl chloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: H2SO4, 27-33percent SO3
2: 84 percent / acetic acid / 24 h / Ambient temperature
3: POCl3, DMF / acetonitrile / 1 h / Heating
4: CH2Cl2; H2O / 2 h / 22 - 26 °C
5: HCl / methanol / 2 h / Ambient temperature
6: MgO, N-methylpyrrolidinone / 3 h / 100 °C
7: 1.) Zn, 2.) HCl / 1.) r.t. to 100 deg C, 1 h, 2.) 2 min
8: POCl3 / acetonitrile / 3.5 h / 22 - 26 °C
With
1-methyl-pyrrolidin-2-one; hydrogenchloride; sulfuric acid; sulfur trioxide; magnesium oxide; N,N-dimethyl-formamide; zinc; trichlorophosphate;
In
methanol; dichloromethane; water; acetic acid; acetonitrile;
DOI:10.1021/jo00090a050
- Guidance literature:
-
Multi-step reaction with 3 steps
1: MgO, N-methylpyrrolidinone / 3 h / 100 °C
2: 1.) Zn, 2.) HCl / 1.) r.t. to 100 deg C, 1 h, 2.) 2 min
3: POCl3 / acetonitrile / 3.5 h / 22 - 26 °C
With
1-methyl-pyrrolidin-2-one; hydrogenchloride; magnesium oxide; zinc; trichlorophosphate;
In
acetonitrile;
DOI:10.1021/jo00090a050
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 84 percent / acetic acid / 24 h / Ambient temperature
2: POCl3, DMF / acetonitrile / 1 h / Heating
3: CH2Cl2; H2O / 2 h / 22 - 26 °C
4: HCl / methanol / 2 h / Ambient temperature
5: MgO, N-methylpyrrolidinone / 3 h / 100 °C
6: 1.) Zn, 2.) HCl / 1.) r.t. to 100 deg C, 1 h, 2.) 2 min
7: POCl3 / acetonitrile / 3.5 h / 22 - 26 °C
With
1-methyl-pyrrolidin-2-one; hydrogenchloride; magnesium oxide; N,N-dimethyl-formamide; zinc; trichlorophosphate;
In
methanol; dichloromethane; water; acetic acid; acetonitrile;
DOI:10.1021/jo00090a050
