(20S)-4,4,14-Trimethyl-3β,20-bis(dimethylamino)-9β,19-cyclo-5α-pregnan-16α-ol

Base Information

• Chemical Name: (20S)-4,4,14-Trimethyl-3β,20-bis(dimethylamino)-9β,19-cyclo-5α-pregnan-16α-ol
• CAS No.: 808-94-6
• Molecular Formula: C28H50N2O
• Molecular Weight: 430.70900
• Mol file: 808-94-6.mol

Synonyms:N,N'-Dimethyl-dihydro-cyclobuxin-D;Cyclovirobuxin-A;4,4-Dimethyl-dihydro-cyclomicrophyllin;

Chemical Property of (20S)-4,4,14-Trimethyl-3β,20-bis(dimethylamino)-9β,19-cyclo-5α-pregnan-16α-ol

Chemical Property:

• PSA: 26.71000
• LogP: 5.27660

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (20S)-4,4,14-Trimethyl-3β,20-bis(dimethylamino)-9β,19-cyclo-5α-pregnan-16α-ol

There total 6 articles about (20S)-4,4,14-Trimethyl-3β,20-bis(dimethylamino)-9β,19-cyclo-5α-pregnan-16α-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + buxozine-C (64938-84-7) → 4,4-Dimethyl-dihydro-cyclomicrophyllin (808-94-6)

Guidance literature:

With 10% Pd/C; hydrogen; In ethanol; water; at 90 ℃; for 6h; under 1520.1 Torr;

DOI:10.1007/s10600-009-9202-8

Reference yield:

cyclovirobuxeine-A → 4,4-Dimethyl-dihydro-cyclomicrophyllin (808-94-6)

Guidance literature:

With hydrogen; acetic acid; platinum(IV) oxide;

DOI:10.1039/j39660001412

Reference yield:

3-Dimethylamino-17-<1-dimethylamino-aethyl>-4-p-toluolsulfonyloxymethyl-16-hydroxy-4,13,14-trimethyl-1,2,3,4,5,8,11,12,13,14,15,16-dodecahydro-17H,19H-cyclopropa<9,10>cyclopentaphenanthren (3296-28-4) → 4,4-Dimethyl-dihydro-cyclomicrophyllin (808-94-6)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) PhCH₂SH, DMF, (ii) Raney-Ni, aq. EtOH

2: H₂, AcOH / PtO₂

With hydrogen; acetic acid; platinum(IV) oxide;

DOI:10.1039/j39660001412

upstream raw materials:

3-Dimethylamino-17-<1-dimethylamino-aethyl>-4-p-toluolsulfonyloxymethyl-16-hydroxy-4,13,14-trimethyl-1,2,3,4,5,8,11,12,13,14,15,16-dodecahydro-17H,19H-cyclopropa<9,10>cyclopentaphenanthren

formaldehyd

buxozine-C