1-[4-(Trifluoromethyl)benzoyl]piperidine-4-carboxylic acid

Base Information

Chemical Name:1-[4-(Trifluoromethyl)benzoyl]piperidine-4-carboxylic acid
CAS No.:856215-36-6
Molecular Formula:C14H14F3NO3
Molecular Weight:301.265
Hs Code.:
European Community (EC) Number:859-581-1
Mol file:856215-36-6.mol

Synonyms:1-[4-(trifluoromethyl)benzoyl]piperidine-4-carboxylic acid;856215-36-6;1-[[4-(Trifluoromethyl)phenyl]carbonyl]-4-piperidinecarboxylic acid;1-{[4-(Trifluoromethyl)phenyl]carbonyl}-4-piperidinecarboxylic acid;SCHEMBL4526323;MFCD08525736;AKOS000118066;CS-0243496;EN300-26440;G36565;Z85885994;1-[4-(trifluoromethyl)benzoyl]piperidine-4-carboxylicacid;1-{[4-(trifluoromethyl)phenyl]carbonyl}piperidine-4-carboxylic acid

Suppliers and Price of 1-[4-(Trifluoromethyl)benzoyl]piperidine-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
1-[4-(Trifluoromethyl)benzoyl]piperidine-4-carboxylicacid
2.5g
$ 664.00

AK Scientific
1-[4-(Trifluoromethyl)benzoyl]piperidine-4-carboxylicacid
500mg
$ 289.00

Total 5 raw suppliers

Chemical Property of 1-[4-(Trifluoromethyl)benzoyl]piperidine-4-carboxylic acid

Chemical Property:

Boiling Point:448.0±45.0 °C(Predicted)
PKA:4.38±0.20(Predicted)
PSA：57.61000
Density:1.367±0.06 g/cm3(Predicted)
LogP:2.58010
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:301.09257779
Heavy Atom Count:21
Complexity:395

Purity/Quality:

99.3% ^*data from raw suppliers

1-[4-(Trifluoromethyl)benzoyl]piperidine-4-carboxylicacid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCC1C(=O)O)C(=O)C2=CC=C(C=C2)C(F)(F)F

Technology Process of 1-[4-(Trifluoromethyl)benzoyl]piperidine-4-carboxylic acid

There total 5 articles about 1-[4-(Trifluoromethyl)benzoyl]piperidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 521322-72-5
1-[1-(4-trifluoromethyl-phenyl)-methanoyl]-piperidine-4-carboxylic acid ethyl ester

: 856215-36-6
1-(4-(trifluoromethyl)benzoyl)piperidine-4-carboxylic acid

Guidance literature:: 1-[1-(4-trifluoromethyl-phenyl)-methanoyl]-piperidine-4-carboxylic acid ethyl ester; With sodium hydroxide; water; In methanol; at 20 ℃; for 20h;

With hydrogenchloride;

Reference yield:

: 1126-09-6
4-carbethoxypiperidine

: 856215-36-6
1-(4-(trifluoromethyl)benzoyl)piperidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 h / 0 - 20 °C

2: methanol; sodium hydroxide; water / 20 h / 20 °C

With methanol; sodium hydroxide; water; triethylamine; In dichloromethane;

Reference yield:

: 329-15-7
4-trifluoromethyl-phenyl acetyl chloride

: 856215-36-6
1-(4-(trifluoromethyl)benzoyl)piperidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 h / 0 - 20 °C

2: methanol; sodium hydroxide; water / 20 h / 20 °C

With methanol; sodium hydroxide; water; triethylamine; In dichloromethane;