6-(4-morpholinyl)-N-[(1-{[4-(trifluoromethyl)phenyl]methyl}-4-piperidinyl)methyl]-3-pyridinamine

Base Information

Chemical Name:6-(4-morpholinyl)-N-[(1-{[4-(trifluoromethyl)phenyl]methyl}-4-piperidinyl)methyl]-3-pyridinamine
CAS No.:856215-40-2
Molecular Formula:C₂₃H₂₉F₃N₄O
Molecular Weight:434.505
Hs Code.:

Synonyms:6-(4-morpholinyl)-N-[(1-{[4-(trifluoromethyl)phenyl]methyl}-4-piperidinyl)methyl]-3-pyridinamine

Suppliers and Price of 6-(4-morpholinyl)-N-[(1-{[4-(trifluoromethyl)phenyl]methyl}-4-piperidinyl)methyl]-3-pyridinamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-(4-morpholinyl)-N-[(1-{[4-(trifluoromethyl)phenyl]methyl}-4-piperidinyl)methyl]-3-pyridinamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-(4-morpholinyl)-N-[(1-{[4-(trifluoromethyl)phenyl]methyl}-4-piperidinyl)methyl]-3-pyridinamine

There total 7 articles about 6-(4-morpholinyl)-N-[(1-{[4-(trifluoromethyl)phenyl]methyl}-4-piperidinyl)methyl]-3-pyridinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 856215-39-9
1-[1-(4-trifluoromethyl-phenyl)-methanoyl]-piperidine-4-carboxylic acid (6-morpholin-4-yl-pyridin-3-yl)-amide

: 856215-40-2
6-(4-morpholinyl)-N-[(1-{[4-(trifluoromethyl)phenyl]methyl}-4-piperidinyl)methyl]-3-pyridinamine

Guidance literature:: 1-[1-(4-trifluoromethyl-phenyl)-methanoyl]-piperidine-4-carboxylic acid (6-morpholin-4-yl-pyridin-3-yl)-amide; With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Heating / reflux;

With sodium hydroxide; In tetrahydrofuran; water;

Reference yield:

: 856215-36-6
1-(4-(trifluoromethyl)benzoyl)piperidine-4-carboxylic acid

: 856215-40-2
6-(4-morpholinyl)-N-[(1-{[4-(trifluoromethyl)phenyl]methyl}-4-piperidinyl)methyl]-3-pyridinamine

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / toluene / 20 h / 0 - 20 °C

2: triethylamine / dichloromethane / 24 h

3: 2.08 h / 200 °C / Microwave irradiation

4: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Heating / reflux

With lithium aluminium tetrahydride; thionyl chloride; triethylamine; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 856215-37-7
1-[1-(4-trifluoromethyl-phenyl)-methanoyl]-piperidine-4-carboxylic acid (6-chloro-pyridin-3-yl)-amide

: 856215-40-2
6-(4-morpholinyl)-N-[(1-{[4-(trifluoromethyl)phenyl]methyl}-4-piperidinyl)methyl]-3-pyridinamine

Guidance literature:: Multi-step reaction with 2 steps

1: 2.08 h / 200 °C / Microwave irradiation

2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Heating / reflux

With lithium aluminium tetrahydride; In tetrahydrofuran;