1H-Indole, 4-bromo-5-methoxy-

Base Information

• Chemical Name: 1H-Indole, 4-bromo-5-methoxy-
• CAS No.: 90858-86-9
• Molecular Formula: C9H8BrNO
• Molecular Weight: 226.073
• Hs Code.: 2933990090
• Mol file: 90858-86-9.mol

Synonyms:4-Bromo-5-methoxyindole;2(5H)-Furanone,4-bromo-5-methoxy;4-bromo-5-methoxy-5H-furan-2-one;4-Bromo-5-methoxyfuran-2(5H)-one;

Chemical Property of 1H-Indole, 4-bromo-5-methoxy-

Chemical Property:

• Boiling Point: 349.2±22.0 °C(Predicted)
• PKA: 15.77±0.30(Predicted)
• PSA: 25.02000
• Density: 1.591±0.06 g/cm3(Predicted)
• LogP: 2.93900
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-5-methoxy-1H-indole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Indole, 4-bromo-5-methoxy-

There total 5 articles about 1H-Indole, 4-bromo-5-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-Bromo-5-methoxy-indole-2-carboxaldehyde (90858-87-0) → 4-bromo-5-methoxy-1H-indole (90858-86-9)

Guidance literature:

Rh(dppp)2Cl; for 18h; Heating;

DOI:10.1021/jo00191a028

Reference yield: 3.0%

2-bromo-4-nitroanisole (5197-28-4) + vinyl magnesium bromide (1826-67-1) → 4-bromo-5-methoxy-1H-indole (90858-86-9)

Guidance literature:

In tetrahydrofuran; at -40 - -20 ℃; for 0.5h;

Reference yield:

2-bromo-1-methoxy-3-methyl-4-nitrobenzene (1196875-90-7) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → 4-bromo-5-methoxy-1H-indole (90858-86-9)

Guidance literature:

2-bromo-1-methoxy-3-methyl-4-nitrobenzene; N,N-dimethyl-formamide dimethyl acetal; In N,N-dimethyl-formamide; at 90 ℃;

With iron; acetic acid; In N,N-dimethyl-formamide; for 1h; Heating / reflux;

upstream raw materials:

4-Bromo-5-methoxy-indole-2-carboxaldehyde

2-bromo-1-methoxy-3-methyl-4-nitrobenzene

N,N-dimethyl-formamide dimethyl acetal

ethyl 4-bromo-5-methoxy-1H-indole-2-carboxylate

Downstream raw materials:

4-bromo-5-methoxy-1-(phenylsulfonyl)-1H-indole

4-bromo-1H-indol-5-ol