1H-Indole, 2-(3-bromophenyl)-

Base Information

• Chemical Name: 1H-Indole, 2-(3-bromophenyl)-
• CAS No.: 93716-78-0
• Molecular Formula: C14H10BrN
• Molecular Weight: 272.144
• Hs Code.: 2933990090
• Mol file: 93716-78-0.mol

Synonyms:2-<3-Brom-phenyl>-indol;

Chemical Property of 1H-Indole, 2-(3-bromophenyl)-

Chemical Property:

• PSA: 15.79000
• LogP: 4.59740

Purity/Quality:

99% ^*data from raw suppliers

2-(3-Bromophenyl)-1H-indole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indole, 2-(3-bromophenyl)-

There total 11 articles about 1H-Indole, 2-(3-bromophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

indole (120-72-9) + 1-Bromo-3-iodobenzene (591-18-4) → 2-(3-bromophenyl)-1H-indole (93716-78-0)

Guidance literature:

With norborn-2-ene; dichloro bis(acetonitrile) palladium(II); potassium carbonate; In N,N-dimethyl acetamide; water; at 70 ℃; regioselective reaction;

DOI:10.1016/j.tetlet.2017.04.066

Reference yield: 90.0%

(E)-1-(1-(3-bromophenyl)ethylidene)-2-phenylhydrazine → 2-(3-bromophenyl)-1H-indole (93716-78-0)

Guidance literature:

With phosphorus pentoxide; phosphoric acid; at 120 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acsmedchemlett.5b00364

Reference yield: 88.0%

3-(3-bromophenyl)propiolic acid (29835-28-7) + 2,2,2-trifluoro-N-(2-iodophenyl)acetamide (143321-89-5) → 2-(3-bromophenyl)-1H-indole (93716-78-0)

Guidance literature:

With potassium carbonate; L-proline; copper(I) bromide; In dimethyl sulfoxide; at 100 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.tetlet.2012.06.023

upstream raw materials:

1-[1-(3-bromophenyl)ethylidene]-2-phenylhydrazine

1-(3-Bromophenyl)ethanone

3-(3-bromophenyl)propiolic acid

2,2,2-trifluoro-N-(2-iodophenyl)acetamide

Downstream raw materials:

2-(3-iodophenyl)-1H-indole

2-(3-bromophenyl)-3-fluoro-1H-indole

2-(3-bromophenyl)-3,3-difluoro-3H-indole

Refernces

• 1、 Chen, Wei-Li,Li, Kun,Liang, Cui,Liang, Wang-Fu,Liao, Wei-Cong,Mo, Dong-Liang,Qiu, Pei-Wen,Su, Gui-Fa. "An iron(iii)-catalyzed dehydrogenative cross-coupling reaction of indoles with benzylamines to prepare 3-aminoindole derivatives". supporting information. p. 9610 - 9616. Retrieved 2021/12/09.
• 2、 Chen, De,Cheng, Chaozhihui,Deng, Wei,Guan, Wenjian,Liu, Yuxuan,Luo, Yongyue,Xiang, Jiannan,Zhang, Jiajia. "Aniline-initiated and Br?nsted acid-catalyzed one-pot reaction toward 2-aryl-3-sulfenylindoles by using α-aminocarbonyl compounds and primary amines with RSSR". . . Retrieved 2020/12/01.