4-IODO-6-INDAZOLECARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 4-IODO-6-INDAZOLECARBOXYLIC ACID METHYL ESTER
• CAS No.: 885519-33-5
• Molecular Formula: C9H7IN2O2
• Molecular Weight: 302.06900

Synonyms:methyl 4-iodo-1H-indazol-6-carboxylate;4-iodo-1H-indazole-6-carboxylic acid methyl ester;4-Iodo-6-indazolecarboxylic acid methyl ester;

Chemical Property of 4-IODO-6-INDAZOLECARBOXYLIC ACID METHYL ESTER

Chemical Property:

• PSA: 54.98000
• LogP: 1.95410

Purity/Quality:

97% ^*data from raw suppliers

Methyl4-iodo-1H-indazole-6-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-IODO-6-INDAZOLECARBOXYLIC ACID METHYL ESTER

There total 3 articles about 4-IODO-6-INDAZOLECARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

methyl 3-amino-5-iodo-4-methylbenzoate (21324-00-5) → methyl 4-iodo-1H-indazol-6-carboxylate (885519-33-5)

Guidance literature:

methyl 3-amino-5-iodo-4-methylbenzoate; With isopentyl nitrate; acetic acid; at 20 ℃; for 0.5h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

methyl 3-amino-4-methyl-5-nitrobenzoate (72922-60-2) → methyl 4-iodo-1H-indazol-6-carboxylate (885519-33-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride; sodium nitrite / water / 1.33 h / Cooling with ice

1.2: 2.33 h / 20 °C / Cooling with ice

2.1: tin(II) chloride dihdyrate / ethyl acetate / 1 h / 60 °C

3.1: hydrogenchloride; sodium nitrite; ammonium tetrafluoroborate / water / 1.33 h / -3 °C

With hydrogenchloride; ammonium tetrafluoroborate; tin(II) chloride dihdyrate; sodium nitrite; In water; ethyl acetate;

Reference yield:

methyl 3-iodo-4-methyl-5-nitrobenzoate (21323-99-9) → methyl 4-iodo-1H-indazol-6-carboxylate (885519-33-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tin(II) chloride dihdyrate / ethyl acetate / 1 h / 60 °C

2: hydrogenchloride; sodium nitrite; ammonium tetrafluoroborate / water / 1.33 h / -3 °C

With hydrogenchloride; ammonium tetrafluoroborate; tin(II) chloride dihdyrate; sodium nitrite; In water; ethyl acetate;

upstream raw materials:

methyl 3-amino-5-iodo-4-methylbenzoate

methyl 3-amino-4-methyl-5-nitrobenzoate

methyl 3-iodo-4-methyl-5-nitrobenzoate

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