Technology Process of 4-BROMO-6-(1H)INDAZOLE CARBOXYLIC ACID
There total 1 articles about 4-BROMO-6-(1H)INDAZOLE CARBOXYLIC ACID which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2,4,6-trifluorobenzaldehyde;
With
N-methoxylamine hydrochloride; potassium carbonate;
In
1,2-dimethoxyethane;
at 50 ℃;
for 16h;
Inert atmosphere;
With
hydrazine hydrate;
In
1,2-dimethoxyethane;
at 100 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium carbonate / acetone / 2 h / Inert atmosphere
2.1: lithium diisopropyl amide / N,N-dimethyl-formamide / 2 h / -78 °C / Inert atmosphere
2.2: 2 h / -78 °C / Inert atmosphere
With
potassium carbonate; lithium diisopropyl amide;
In
N,N-dimethyl-formamide; acetone;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium carbonate / acetone / 2 h / Inert atmosphere
2.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere
2.2: 2 h / -78 °C / Inert atmosphere
With
potassium carbonate; lithium diisopropyl amide;
In
tetrahydrofuran; acetone;
